DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Csk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001025210.1	Gene:	Csk / 315707	RGDID:	1308800	Length:	450	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	167/441 - (37%)
Similarity:	252/441 - (57%)	Gaps:	26/441 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKP----KALLGLER 407
            :|.|.|......||...|.....::..::: :|:|.|:.:|..|.||:|||:.    ||...|..
  Rat    15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSL 79

  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYY 471
            ..|:.|.::|::||.|| ...:.|.|:||:|:. .|.|||.:..   :..|:||.|..:| .:..
  Rat    80 MPWFHGKITREQAERLL-YPPETGLFLVRESTNYPGDYTLCVSC---EGKVEHYRIMYHA-SKLS 139

  Fly   472 LSEKHCCETIPDLINYHRHNSGGLACRL-KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSG 535
            :.|:...|.:..|:.::..::.||..|| |....:..|..........|.::..||.|::.:|.|
  Rat   140 IDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKG 204

  Fly   536 QFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHR-PIYIVTE 599
            :||.|..|.:||: ..|||.:|....:: .|:.||.|||:|:|.|||||.||..:.: .:|||||
  Rat   205 EFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267

  Fly   600 YMKHGSLLNYLRRHEKTLIGNMGLL---LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVV 661
            ||..|||::|||...::::|...||   ||:|    :.|.|||.:|::||||||||.||..:||.
  Rat   268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC----EAMEYLEGNNFVHRDLAARNVLVSEDNVA 328

  Fly   662 KVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGR 726
            ||:||||.:.....|.|.    |.|:||..||.|...:||:|||||::|:|:|||::.|::||.|
  Rat   329 KVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389

  Fly   727 LKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            :...:||.||::|..::.|..|...:|||||.||......||.|..|.:||
  Rat   390 IPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/51 (31%)
		SH2_Tec_family	403..505	CDD:198188	30/103 (29%)
		PTKc_Tec_like	521..778	CDD:173637	117/261 (45%)
		Pkinase_Tyr	526..777	CDD:285015	114/254 (45%)
Csk	NP_001025210.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41240	9..70		16/54 (30%)
		SH3_CSK	11..67	CDD:212703	16/51 (31%)
		SH2_csk_like	78..175	CDD:198190	29/101 (29%)
		PTKc_Csk	188..443	CDD:133213	118/263 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810