DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Abl1

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001094320.1 Gene:Abl1 / 311860 RGDID:1584969 Length:1143 Species:Rattus norvegicus


Alignment Length:505 Identity:193/505 - (38%)
Similarity:280/505 - (55%) Gaps:55/505 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   287 GGGSC------------TPTSLQPQ--SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
            ||..|            ..:..:||  |....:.....||.|             |:...||   
  Rat    35 GGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAG-------------PSENDPN--- 83

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKAL 402
                    |.||||.|.|.....||:.|..:..|:..:....|.........|::||||:.|  :
  Rat    84 --------LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITP--V 138

  Fly   403 LGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNA 466
            ..||::.||.|.:||..||.||..| ..|.|:||:| |:.|..::||..   :..|.||.|...:
  Rat   139 NSLEKHSWYHGPVSRNAAEYLLSSG-INGSFLVRESESSPGQRSISLRY---EGRVYHYRINTAS 199

  Fly   467 RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS--HDKWEIHPMELMLM 529
            ..:.|:|.:....|:.:|:::|...:.||...|......|..|...|:|  :||||:...::.:.
  Rat   200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMK 264

  Fly   530 EELGSGQFGVVRRGKWRG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRP 593
            .:||.||:|.|..|.|:. |:..|||.:||.||..::|::||.||.:::|||||||.|||::..|
  Rat   265 HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP 329

  Fly   594 IYIVTEYMKHGSLLNYLR---RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLV 655
            .||:||:|.:|:||:|||   |.|.:.:    :||.|..|:|..|.|||:.|:||||||||||||
  Rat   330 FYIITEFMTYGNLLDYLRECNRQEVSAV----VLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390

  Fly   656 GSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            |..::||||||||:|.:..|.||:..|.||||||..||.|.|.:||.||||||:|||:|||.|.|
  Rat   391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 455

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            ..||..:..::|.|.:::...:|:|:.|.:::|::|:.||...|.:||:|
  Rat   456 MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 17/52 (33%)
SH2_Tec_family 403..505 CDD:198188 33/102 (32%)
PTKc_Tec_like 521..778 CDD:173637 122/254 (48%)
Abl1NP_001094320.1 SH3_Abl 84..137 CDD:212784 17/52 (33%)
SH2_ABL 142..235 CDD:198189 32/96 (33%)
PTKc_Abl 254..516 CDD:270645 124/256 (48%)
FABD 1019..1143 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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