DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Map3k11

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001013168.1 Gene:Map3k11 / 309168 RGDID:1359261 Length:850 Species:Rattus norvegicus


Alignment Length:540 Identity:132/540 - (24%)
Similarity:193/540 - (35%) Gaps:196/540 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 GSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNS 341
            ||....|.||||||                                  ||:...|:|.:.|   :
  Rat    14 GSWNGSGSGGGGGS----------------------------------GGVRPEGSPKATA---A 41

  Fly   342 HFVKLVVALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWWKVKDALGNVGYIPSNYVKPKA 401
            :...:..||:.::.....:|:|.|....||:.     ...|.|| .....|.||..|||||.   
  Rat    42 YANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWW-AGQVGGQVGIFPSNYVS--- 102

  Fly   402 LLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNA 466
                                                                             
  Rat   103 ----------------------------------------------------------------- 102

  Fly   467 RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEE 531
                                    ..||      ..||:     .|..         .||.|.|.
  Rat   103 ------------------------RGGG------PPPCE-----VASF---------QELRLEEV 123

  Fly   532 LGSGQFGVVRRGKWRGSIDTAVKMMKEG-----TMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            :|.|.||.|.||.|||.: .|||..::.     :::.:...:||::...|.|||::.|..||.:.
  Rat   124 IGIGGFGKVYRGSWRGEL-VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEE 187

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERH---NYIHRDLAA 650
            ..:.:|.||...|.|       .:.|.|..   .:|::..:|:::||.||...   ..|||||.:
  Rat   188 PNLCLVMEYAAGGPL-------SRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKS 245

  Fly   651 RNCLV-----GSE---NVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            .|.|:     |.:   ..:|:.||||||........|:.||   ..|..|||:..:.||..||||
  Rat   246 NNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGT---YAWMAPEVIKASTFSKGSDVW 307

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDVMKLCWSHGPEER 767
            ::|||:||:.| |::||..:....|.    .|:.:.|     |.:|.:....:|..||:..|..|
  Rat   308 SFGVLLWELLT-GEVPYRGIDCLAVA----YGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRR 367

  Fly   768 PAFRVLMDQL-ALVAQTLTD 786
            |.|..::.|| ||.||.|.:
  Rat   368 PDFASILQQLEALEAQVLRE 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 18/57 (32%)
SH2_Tec_family 403..505 CDD:198188 3/101 (3%)
PTKc_Tec_like 521..778 CDD:173637 90/281 (32%)
Map3k11NP_001013168.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..37 10/52 (19%)
SH3_MLK1-3 46..103 CDD:212992 18/149 (12%)
STKc_MLK3 114..380 CDD:271049 90/290 (31%)
Leucine-zipper 1 404..425
Leucine-zipper 2 439..460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..850
Blue background indicates that the domain is not in the aligned region.

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