DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Map3k10

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001382027.1 Gene:Map3k10 / 308463 RGDID:1308381 Length:940 Species:Rattus norvegicus


Alignment Length:466 Identity:118/466 - (25%)
Similarity:181/466 - (38%) Gaps:156/466 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 ALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERY 408
            |::.::|:...:|:|.:....:|:.     ...|.||..:...|.||..|||||.|.|       
  Rat    23 AVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAA------- 80

  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLS 473
                                                                             
  Rat    81 ----------------------------------------------------------------- 80

  Fly   474 EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFG 538
                                      .::|.|..:|.         ||...||.|.|.:|.|.||
  Rat    81 --------------------------PAAPTDLQLPQ---------EIPFHELQLEEIIGVGGFG 110

  Fly   539 VVRRGKWRGSIDTAVKMM-----KEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVT 598
            .|.|..|||. :.|||..     ::..::.:...:||::...|||||::.|.|.|.....:.:|.
  Rat   111 KVYRALWRGE-EVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVM 174

  Fly   599 EYMKHGSLLNYLRRHEKTLIGNM---GLLLDMCIQVSKGMTYLERHN-----YIHRDLAARNCLV 655
            ||.:.|:|       .:.|.|..   .:|::..:||::||.||  ||     .|||||.:.|.|:
  Rat   175 EYARGGAL-------SRVLAGRRVPPHVLVNWAVQVARGMNYL--HNDAPVPIIHRDLKSINILI 230

  Fly   656 --GSEN------VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712
              ..||      |:|:.||||||........|:.||   ..|..|||:..:.||..||||::|||
  Rat   231 LEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT---YAWMAPEVIRLSLFSKSSDVWSFGVL 292

  Fly   713 MWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDVMKLCWSHGPEERPAFRV 772
            :||:.| |::||..:....|.    .|:.:.|     |.:|.:....:::.||...|..||.|..
  Rat   293 LWELLT-GEVPYREIDALAVA----YGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGS 352

  Fly   773 LMDQLALVAQT 783
            ::.||.::.|:
  Rat   353 ILKQLEVIEQS 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 16/54 (30%)
SH2_Tec_family 403..505 CDD:198188 1/101 (1%)
PTKc_Tec_like 521..778 CDD:173637 94/282 (33%)
Map3k10NP_001382027.1 SH3_MLK1-3 20..76 CDD:212992 14/52 (27%)
Protein Kinases, catalytic domain 103..360 CDD:473864 90/274 (33%)
Leucine-zipper 1 384..405
Leucine-zipper 2 419..440
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..599
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..916
Blue background indicates that the domain is not in the aligned region.

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