Protein Alignment Btk and Map3k21

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001418265.1
• Gene: Map3k21 / 307950
• RGDID: 1306091
• Length: 996
• Species: Rattus norvegicus
• Alignment Length: 507
• Identity: 126/507 - (24%)
• Similarity: 195/507 - (38%)
• Gaps: 160/507 - (31%)

  Fly   323 MPGGIPTPGTPNSKAKDNSHFVK--LVVALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWW 380
            :|....|.||..|..:|:|....  :..|||.::|....:|||::....||:.     ...|.||
  Rat     3 LPVAEGTAGTSLSPVRDDSGSSSSGMWAALYDYEARGEDELSLKRGQLVEVLSQDAAVSGDEGWW 67

  Fly   381 --KVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGL 443
              :|:..|   |..|::||.|
  Rat    68 AGQVQRRL---GIFPASYVAP-------------------------------------------- 85

  Fly   444 YTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPV 508
                                             |....|                 .|.|..||.
  Rat    86 ---------------------------------CSSVSP-----------------PSPPPPRPC 100

  Fly   509 PPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-----EGTMSEDDFIE 568
            .|.    |..:|    .|.|.|.:|:|.||.|.|..|:|. :.|||..:     :...:.:....
  Rat   101 SPV----HVDFE----RLELKELIGAGGFGQVYRATWQGQ-EVAVKAARRDPEQDAAAAAESVRR 156

  Fly   569 EAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL------------RRHEKTLIGNM 621
            ||::...|:|||::||.|||.:...:.:|.|:.:.|:|...|            ||..:.   ..
  Rat   157 EARLFAMLRHPNIIQLRGVCLQQPHLCLVLEFARGGALNRALAAAAPDPRVPGPRRARRI---PP 218

  Fly   622 GLLLDMCIQVSKGMTYLERHNYI---HRDLAARNCLVGSE--------NVVKVADFGLARYVLDD 675
            .:|::..:|:::||.||.....:   ||||.:.|.|:..:        ..:|:.||||||.....
  Rat   219 HVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT 283

  Fly   676 QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGI 740
            ...|:.||   ..|..|||:..:.||..||:|:||||:||:.| |::||..:....|.    .|:
  Rat   284 TRMSAAGT---YAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVA----YGV 340

  Fly   741 ILEK-----PKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ-TLTD 786
            .:.|     |.:|.:....:||.||...|..||:|.:::.||..:.: .|||
  Rat   341 AVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILKQLTAIEEAVLTD 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/59 (31%)
		SH2_Tec_family	403..505	CDD:198188	4/101 (4%)
		PTKc_Tec_like	521..778	CDD:173637	87/289 (30%)
Map3k21	NP_001418265.1	SH3	28..84	CDD:473055	17/58 (29%)
		STKc_MLK4	115..385	CDD:271048	85/281 (30%)