DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk29A and HCK

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:509 Identity:201/509 - (39%)
Similarity:293/509 - (57%) Gaps:46/509 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 GGGGGSCTPTSLQPQSSL------TTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHF 343
            ||...|.|.||..|...:      :|.|..|...|.|             |||...:.::|    
Human    33 GGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSN-------------TPGIREAGSED---- 80

  Fly   344 VKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLER 407
             .:|||||.::||...|||.:|..:..|:::|.| |||.:. |....||||||||  ..:..||.
Human    81 -IIVVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYV--ARVDSLET 141

  Fly   408 YEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQ--SHVKHYHIKQNARC 468
            .||:...:||:.|| .||..|:..|.|::|.| :|||.|:||:....|:  ..||||.|:.....
Human   142 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNG 206

  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPTAGLSHDKWEIHPMELMLMEE 531
            .:|:|.:....|:.:|:::::..:.|| |:..|.||  .:|..|   ...|.|||....|.|.::
Human   207 GFYISPRSTFSTLQELVDHYKKGNDGL-CQKLSVPCMSSKPQKP---WEKDAWEIPRESLKLEKK 267

  Fly   532 LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYI 596
            ||:||||.|....:......|||.||.|:||.:.|:.||.||..|||..||:|:.|.:| .||||
Human   268 LGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK-EPIYI 331

  Fly   597 VTEYMKHGSLLNYLRRHEKTLIGN---MGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSE 658
            :||:|..||||::|:..|    |:   :..|:|...|:::||.::|:.|||||||.|.|.||.:.
Human   332 ITEFMAKGSLLDFLKSDE----GSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392

  Fly   659 NVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMP 723
            .|.|:|||||||.:.|::||:..|.||||||..||.:|:..|:.|||||::|:|:.||.|.|::|
Human   393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP 457

  Fly   724 YGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |..:.|.||:..::||..:.:|::|.:|:|::|..||.:.|||||.|..:...|
Human   458 YPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 26/53 (49%)
SH2_Tec_family 403..505 CDD:198188 37/107 (35%)
PTKc_Tec_like 521..778 CDD:173637 117/260 (45%)
Pkinase_Tyr 526..777 CDD:285015 115/253 (45%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SH3 82..137 CDD:302595 26/57 (46%)
SH2_Src_HCK 140..243 CDD:198226 36/103 (35%)
PKc_like 254..524 CDD:304357 119/263 (45%)
Pkinase_Tyr 262..511 CDD:285015 115/253 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D539311at2759
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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