DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Txk

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001019426.1 Gene:Txk / 305311 RGDID:1306481 Length:526 Species:Rattus norvegicus


Alignment Length:473 Identity:231/473 - (48%)
Similarity:311/473 - (65%) Gaps:23/473 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   325 GGI------PTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK 383
            ||:      |.|..|....::...    |.|||.|...|..:|:|::..||.:::....|||:.:
  Rat    62 GGVQPSKRRPLPPLPQEFTEERIR----VKALYDFLPREPCNLALKRAEEYLILERCDPHWWRAR 122

  Fly   384 DALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSL 448
            |.|||.|.||||||....|..||.||||..:::|.:.|.||:|..|||.|:||.|...|.||:|:
  Rat   123 DRLGNEGLIPSNYVTENRLTNLETYEWYHKNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISV 187

  Fly   449 HTKV---PQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK-----SSPCD 505
            .|:.   .||.:|||.||:|...::|::|:|...::|:||.||::|:.||..||:     ...| 
  Rat   188 FTRARRHTQSSIKHYQIKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSC- 251

  Fly   506 RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEA 570
              :|.|:|.|::||||.|.||..::|:||||||||..|:||..|..|:|.:.||:|||:||||||
  Rat   252 --LPATSGFSYEKWEIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEA 314

  Fly   571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGM 635
            |||.||.|..||||||||.:.:|:|||||:|::|.||:|||..:..|  ...|||.||..:.:||
  Rat   315 KVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGKL--PKALLLSMCQDICEGM 377

  Fly   636 TYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRF 700
            .|||:..|||||||||||||.|..|||::|||:|||||||:|.||.|.|||:||:||||.::.::
  Rat   378 AYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKY 442

  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            |||||||::||||||:||.||||:....|.:|||.:.:|..|.:|......||.||..||...|:
  Rat   443 SSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPK 507

  Fly   766 ERPAFRVLMDQLALVAQT 783
            .||.|..|:..||.:|:|
  Rat   508 GRPTFAELLQVLAEIAET 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 24/52 (46%)
SH2_Tec_family 403..505 CDD:198188 44/109 (40%)
PTKc_Tec_like 521..778 CDD:173637 145/256 (57%)
TxkNP_001019426.1 SH3_TXK 84..138 CDD:212840 24/57 (42%)
SH2_Tec_Txk 142..247 CDD:198261 44/104 (42%)
Protein Kinases, catalytic domain 265..520 CDD:473864 145/256 (57%)
Blue background indicates that the domain is not in the aligned region.

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