Protein Alignment Btk and ret

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_858048.2
• Gene: ret / 30512
• ZFINID: ZDB-GENE-980526-307
• Length: 1106
• Species: Danio rerio
• Alignment Length: 1052
• Identity: 236/1052 - (22%)
• Similarity: 371/1052 - (35%)
• Gaps: 362/1052 - (34%)

  Fly    34 LMSERLYDVVKSGSMVKRAQNKKRF-TPVNY----KHR-----WFELTK--------RTFSYFDV 80
            |.:|.:|...:.||.:.:..:.:.| |...|    .||     ||.:.:        :|..:.|.
Zfish    29 LYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTSWFHIDEASGVLYLNKTLEWSDF 93

  Fly    81 ENVERRRERGRIHLKGVRLVEEATVS-GEGGDP-----------------FAPDGYPFQVGYCEI 127
            .:         :....||..::.|:. |....|                 |..|..| ..|..|:
Zfish    94 SS---------LRSGSVRSPKDLTLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAP-SCGQVEL 148

  Fly   128 SA------SANSHQLENGNGGG-------SGVGI-------EGQQSGRAVP------QYTLYVIA 166
            |.      .:|.|..||...|.       :.:.|       .|..:|.:||      ...|.|.|
Zfish   149 STLCFPEKISNPHITENREPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTA 213

  Fly   167 NSEKERSEWIRAIRQVC---------------------EDSNTPKSYRYHPGLWSGK---KWSCC 207
            ..::|..| :..:..||                     ||.|:|    |..|..:..   ::...
Zfish   214 QVDREEKE-VYHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSP----YVNGTDTEDVLVEFDRS 273

  Fly   208 KGLSRTTFGCRAAAHWREANNNPSNGSSPAQNS-TRSISPNSSTTNSQFSLQH--NSSGSLGGGV 269
            :|   |.||   .....:.:..|...::..||. ..::..|.|...:.|:::|  ....::.|.|
Zfish   274 EG---TVFG---TLFVYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGNV 332

  Fly   270 GGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLL-DANMPGG------- 326
                              .|:.....|:...:|:..:|...||   |.|: |...||.
Zfish   333 ------------------RGTVHEYKLKLSQNLSVTEQRSFLL---GYLVNDTTFPGPEGTVLLH 376

  Fly   327 -----IPTP---------GTPNSKAKDNSHFVKLVVA-LYPFKAIEGGDLSLEKNAEYEVID--- 373
                 :|.|         .|.:.||...|...|:.|. ...||.|       :...:.|::|
Zfish   377 FNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGI-------DVTYQLEIVDRNI 434

  Fly   374 --DSQEHWWKVKDALG---NVGYIPSNYVKPKALLGLERYEWYVGDMSRQ--------------- 418
              ::|..:|.|..|..   |.|.:..|..|.......:..|:.|....:|
Zfish   435 TAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQG 499

  Fly   419 RAESL-------------LKQGDKE---------GCFVVRKSSTKGL-----------------Y 444
            .|:||             .::||.|         |....|:...||:                 |
Zfish   500 EADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDGY 564

  Fly   445 TLSLHTK----VPQSHVKH----------YHIKQ-NARCEYYLSEKHC---------------CE 479
            ..::.:|    .||.....          |.||. :..|  |..|..|               |:
Zfish   565 CDAIESKNISICPQDCSSEAIIGGYERDLYGIKAGHGTC--YCFEGKCFCERDEPEDDICNDMCK 627

  Fly   480 TIPD------------LINY--HRHNSGGLACRLKSSPCDRPVPPTAG-------------LSHD 517
            |:..            |.:|  ||::.            ..|.||.|.             :|:.
Zfish   628 TVIATGIILSFIVSVLLSSYFIHRYHK------------TTPKPPIASAEMTFRRPAQSYPISYS 680

  Fly   518 ---------------------------KWEIHPMELMLMEELGSGQFG-VVRRGKWR-----GSI 549
                                       |||.....|:|.:.||.|:|| ||:...:|     |..
Zfish   681 ANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYT 745

  Fly   550 DTAVKMMKEGTMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRR 612
            ..||||:||.....:  |.:.|..::.::.||:::::||.||:..|:|::.||.|:|||.|:||.
Zfish   746 TVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRE 810

  Fly   613 HEK---TLIGN------------------MGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            ..|   :.:||                  ||.|:....|:|:||.||.....:||||||||.||.
Zfish   811 SRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVA 875

  Fly   657 SENVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            ....:|::||||:|.|. :|.|......:.|:||...|.|....::::||||::|||:|||.|.|
Zfish   876 EGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG 940

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVL-----------M 774
            ..||..:....:...::.|..:|||::|..|:|::|..||....::||.|..:           .
Zfish   941 GNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSR 1005

  Fly   775 DQLALVAQTLTD 786
            |.|.|.|.|..|
Zfish  1006 DYLDLAASTPAD 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	49/263 (19%)
		SH3_Tec_like	346..399	CDD:212702	13/61 (21%)
		SH2_Tec_family	403..505	CDD:198188	30/199 (15%)
		PTKc_Tec_like	521..778	CDD:173637	100/297 (34%)
ret	NP_858048.2	RET_CLD1	23..140	CDD:465485	21/119 (18%)
		CA	186..256	CDD:214520	14/70 (20%)
		RET_CLD3	251..364	CDD:465516	27/143 (19%)
		RET_CLD4	388..499	CDD:465517	22/117 (19%)
		PTKc_RET	715..1004	CDD:173631	99/288 (34%)