Protein Alignment Btk and Abl2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001382059.1
• Gene: Abl2 / 304883
• RGDID: 1590898
• Length: 1182
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 211/554 - (38%)
• Similarity: 298/554 - (53%)
• Gaps: 61/554 - (11%)

  Fly   233 GSSPAQNSTRSISPNSSTTNSQFSL--QHNSSGS-LGGGVGGGLGGGGSLGLGGGGGGGGSCTPT 294
            |||.|:.|.|...|...|.::.|::  ||:...| :..|..|...||.|              |.
  Rat    24 GSSAARPSGRRRDPVGRTADAGFNVFTQHDHFASCVEDGFEGDKTGGSS--------------PE 74

  Fly   295 SLQPQSSLTTFKQSPTLLN------GNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPF 353
            .|..........|:   ||      ....||.|       |...||           |.||||.|
  Rat    75 VLHRPFGCDAESQA---LNEAIRWSSKENLLGA-------TESDPN-----------LFVALYDF 118

  Fly   354 KAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQ 418
            .|.....||:.|..:..|:..:|...|....:....|::||||:.|  :..||::.||.|.:||.
  Rat   119 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITP--VNSLEKHSWYHGPVSRS 181

  Fly   419 RAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIP 482
            .||.|| .....|.|:||:| |:.|..::||..   :..|.||.|......:.|::.:....|:.
  Rat   182 AAEYLL-SSLINGSFLVRESESSPGQLSISLRY---EGRVYHYRINTTTDSKVYVTAESRFSTLA 242

  Fly   483 DLINYHRHNSGGLACRL--KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW 545
            :|:::|...:.||...|  .:..|::|........|||||:...::.:..:||.||:|.|..|.|
  Rat   243 ELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 307

  Fly   546 RG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNY 609
            :. |:..|||.:||.||..::|::||.||.:::|||||||.|||:...|.|||||||.:|:||:|
  Rat   308 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372

  Fly   610 LR---RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARY 671
            ||   |.|.|.:    :||.|..|:|..|.|||:.|:|||||||||||||..:|||||||||:|.
  Rat   373 LRECSREEVTAV----VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 433

  Fly   672 VLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV 736
            :..|.||:..|.||||||..||.|.|..||.||||||:|||:|||.|.|..||..:..::|.:.:
  Rat   434 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLL 498

  Fly   737 QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            ::|..:|:|:.|..::|::|:.||...|.:||:|
  Rat   499 EKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/52 (35%)
		SH2_Tec_family	403..505	CDD:198188	31/104 (30%)
		PTKc_Tec_like	521..778	CDD:173637	126/254 (50%)
Abl2	NP_001382059.1	SH3_Abl	111..164	CDD:212784	18/52 (35%)
		SH2_ABL	169..262	CDD:198189	30/96 (31%)
		PTKc_Abl	281..543	CDD:270645	128/256 (50%)
		FABD	1063..1182	CDD:197885