Protein Alignment Btk and Tnk1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006246766.1
• Gene: Tnk1 / 303247
• RGDID: 1310113
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 305
• Identity: 103/305 - (33%)
• Similarity: 155/305 - (50%)
• Gaps: 41/305 - (13%)

  Fly   493 GGLACRLKSSPCDRPVPP-TAGLSHDKWEIHPMELMLM-----------EELGSGQFGVVRRGKW 545
            ||.|      |..:.:|| :..|.|    :|..|..|.           |.||||.||||.:|.|
  Rat   154 GGFA------PEQKEIPPYSDSLPH----LHEPEGGLKCLIPEGAVCRGELLGSGCFGVVHQGLW 208

  Fly   546 R----GSIDTAVKMMK---EGTMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYM 601
            .    .||..|||.::   ||.|..:  ||:.|..||.||:||::::|:|:. ..:|:.:|.|..
  Rat   209 TLPGGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLV-LGQPLQMVMELA 272

  Fly   602 KHGSLLNYLRRHEKTLIGNMGLLLDMCI---QVSKGMTYLERHNYIHRDLAARNCLVGSENVVKV 663
            ..|||  :.|......:..:.:.| :|:   |::..|.||.....:|||||.||.|:.|...:||
  Rat   273 PLGSL--HARLTAPAPMPPLPVTL-LCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRKIKV 334

  Fly   664 ADFGLARYV--LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGR 726
            |||||.|.:  ...:|...|....|..|..||.|....||:.||||.:||.:||:|:.|:.|:..
  Rat   335 ADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSAASDVWMFGVTLWEMFSGGEEPWAG 399

  Fly   727 LKNTEVVERVQRG-IILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            :....:::|:::. ..|.||..|::.:|.:...||:..|.:||.|
  Rat   400 VPPYLILQRLEKDRARLPKPALCSRALYSLALRCWAPHPADRPTF 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	4/11 (36%)
		PTKc_Tec_like	521..778	CDD:173637	95/276 (34%)
Tnk1	XP_006246766.1	SAM_TNK-like	89..140	CDD:188938
		Protein Kinases, catalytic domain	193..453	CDD:473864	92/256 (36%)
		SH3	<468..509	CDD:473055
		UBA_like_SF	668..711	CDD:473871
		UBA_like_SF	698..737	CDD:473871