DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and jak2b

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_571162.1	Gene:	jak2b / 30298	ZFINID:	ZDB-GENE-980526-123	Length:	1126	Species:	Danio rerio

Alignment Length:	293	Identity:	100/293 - (34%)
Similarity:	152/293 - (51%)	Gaps:	45/293 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 LMLMEELGSGQFGVVRRGKW------RGSIDTAVKMMKEGTMSE-DDFIEEAKVMTKLQHPNLVQ 583
            |:.:::||.|.||.|...::      .|.: .|||.::..|... .||..|.:::..|||.|:|:
Zfish   834 LIFLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTTEHIRDFEREIEILKSLQHENIVK 897

  Fly   584 LYGVC--SKHRPIYIVTEYMKHGSLLNYLRR------HEKTLIGNMGLLLDMCIQVSKGMTYLER 640
            ..|||  :..|.:.:|.||:.:|||.:||.:      |:|        |:....|:.|||.||..
Zfish   898 YKGVCYGAGRRNLRLVMEYLPYGSLRDYLNKNRDRIDHQK--------LVHYASQICKGMEYLAT 954

  Fly   641 HNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            ..|||||||.||.||.||..||:.||||.:.:..|:  |......:.||.|..||.|..::||..
Zfish   955 KRYIHRDLATRNILVESECRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWHAPESLTESKFSVA 1019

  Fly   704 SDVWAYGVLMWEIFT-----C----------GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIY 753
            ||||::||:::|:||     |          |....|:.....::|.::||..|.:|..|..|::
Zfish  1020 SDVWSFGVVLYELFTYSDKLCSPPTVFLSMVGGDKQGQTIVYHLIELLKRGNRLPQPMGCPTEMF 1084

  Fly   754 DVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            ::|:.||.:.|..||.|:    :|||....:.|
Zfish  1085 EIMQECWDNDPSLRPNFK----ELALRVDLIRD 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	96/283 (34%)
		Pkinase_Tyr	526..777	CDD:285015	96/282 (34%)
jak2b	NP_571162.1	B41	29..262	CDD:214604
		FERM_B-lobe	144..253	CDD:271216
		FERM_C_JAK2	258..370	CDD:270141
		SH2_Jak2	370..466	CDD:198242
		PKc_like	528..791	CDD:304357
		Pkinase_Tyr	528..790	CDD:285015
		PKc_like	829..1112	CDD:304357	99/290 (34%)
		TyrKc	834..1104	CDD:197581	96/282 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910