Protein Alignment Btk and jak1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_571148.1
• Gene: jak1 / 30280
• ZFINID: ZDB-GENE-980526-142
• Length: 1153
• Species: Danio rerio
• Alignment Length: 433
• Identity: 118/433 - (27%)
• Similarity: 197/433 - (45%)
• Gaps: 79/433 - (18%)

  Fly   383 KDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLS 447
            ::.:..:.:|....||..|.|.:...:|..|..                           |:.:.
Zfish   749 EECVDRIPWIAPECVKDTANLSIAADKWSFGTT---------------------------LWEIC 786

  Fly   448 LHTKVPQSHVKHYHIKQNARCEYYLSE---------------KHCCETIPDLINYHRHNSGGLAC 497
            .:.::|   :|...:.:..|  :|.::               .||....|....:.|.....:..
Zfish   787 YNGEIP---LKDKKLTEKER--FYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFRAIVRDIVM 846

  Fly   498 RLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVR------RGKWRGSIDTAVKMM 556
            ..|.:|..:|||.   |..|........|..:.:||.|.||.|.      ||...|.: .|||.:
Zfish   847 VEKQNPSIQPVPM---LEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGEL-VAVKSL 907

  Fly   557 KEGTMSE--DDFIEEAKVMTKLQHPNLVQLYGVCSKH--RPIYIVTEYMKHGSLLNYLRRHEKTL 617
            |.....|  ::...|..::.:|.|.|:|:..|:|::.  |.|.::.|::..|||..||.|::..:
Zfish   908 KPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHI 972

  Fly   618 IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSS 680
              |:..||:..:|:.:||.||...|||||||||||.||.:|..||:.||||.:.:.|::  ||..
Zfish   973 --NLKTLLNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYYTVK 1035

  Fly   681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-----CGKM---------PYGRLKNTE 731
            .....|:.|..||.|.:.:|...||||::||.|:|:.|     |..|         .:|::..|.
Zfish  1036 DDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQMTVTR 1100

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
            :|:.::.|..|.:|..|::::|::|:.||...||:|..|:.|:
Zfish  1101 LVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRINFKSLI 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	2/15 (13%)
		SH2_Tec_family	403..505	CDD:198188	14/116 (12%)
		PTKc_Tec_like	521..778	CDD:173637	95/280 (34%)
jak1	NP_571148.1	FERM_F1	34..127	CDD:465733
		FERM_F2	145..275	CDD:436450
		FERM_C_JAK1	280..422	CDD:275412
		SH2_Jak1	422..523	CDD:198241
		PTK_Jak1_rpt1	580..845	CDD:270662	16/127 (13%)
		Protein Kinases, catalytic domain	867..1150	CDD:473864	95/280 (34%)