DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk29A and jak1

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_571148.1 Gene:jak1 / 30280 ZFINID:ZDB-GENE-980526-142 Length:1153 Species:Danio rerio


Alignment Length:433 Identity:118/433 - (27%)
Similarity:197/433 - (45%) Gaps:79/433 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   383 KDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLS 447
            ::.:..:.:|....||..|.|.:...:|..|..                           |:.:.
Zfish   749 EECVDRIPWIAPECVKDTANLSIAADKWSFGTT---------------------------LWEIC 786

  Fly   448 LHTKVPQSHVKHYHIKQNARCEYYLSE---------------KHCCETIPDLINYHRHNSGGLAC 497
            .:.::|   :|...:.:..|  :|.::               .||....|....:.|.....:..
Zfish   787 YNGEIP---LKDKKLTEKER--FYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFRAIVRDIVM 846

  Fly   498 RLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVR------RGKWRGSIDTAVKMM 556
            ..|.:|..:|||.   |..|........|..:.:||.|.||.|.      ||...|.: .|||.:
Zfish   847 VEKQNPSIQPVPM---LEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGEL-VAVKSL 907

  Fly   557 KEGTMSE--DDFIEEAKVMTKLQHPNLVQLYGVCSKH--RPIYIVTEYMKHGSLLNYLRRHEKTL 617
            |.....|  ::...|..::.:|.|.|:|:..|:|::.  |.|.::.|::..|||..||.|::..:
Zfish   908 KPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHI 972

  Fly   618 IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSS 680
              |:..||:..:|:.:||.||...|||||||||||.||.:|..||:.||||.:.:.|::  ||..
Zfish   973 --NLKTLLNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYYTVK 1035

  Fly   681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-----CGKM---------PYGRLKNTE 731
            .....|:.|..||.|.:.:|...||||::||.|:|:.|     |..|         .:|::..|.
Zfish  1036 DDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQMTVTR 1100

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
            :|:.::.|..|.:|..|::::|::|:.||...||:|..|:.|:
Zfish  1101 LVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRINFKSLI 1143

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 2/15 (13%)
SH2_Tec_family 403..505 CDD:198188 14/116 (12%)
PTKc_Tec_like 521..778 CDD:173637 95/280 (34%)
Pkinase_Tyr 526..777 CDD:285015 95/275 (35%)
jak1NP_571148.1 B41 35..276 CDD:214604
FERM_C_JAK1 280..422 CDD:275412
SH2_Jak1 422..523 CDD:198241
PTK_Jak1_rpt1 580..845 CDD:270662 16/127 (13%)
Pkinase_Tyr 580..844 CDD:285015 16/126 (13%)
PKc_like 867..1150 CDD:304357 95/280 (34%)
Pkinase_Tyr 872..1146 CDD:285015 95/275 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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