DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Fer

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001382687.1 Gene:Fer / 301737 RGDID:1306273 Length:823 Species:Rattus norvegicus


Alignment Length:416 Identity:153/416 - (36%)
Similarity:230/416 - (55%) Gaps:42/416 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 GYIPSNYVKPKALLG---------------LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSS 439
            |.|.|    ||::||               |..::||.|.:.|..|:.||||   :|.|:||:|.
  Rat   430 GIIKS----PKSVLGSSTQLSDVISVGEKPLAEHDWYHGAIPRIEAQELLKQ---QGDFLVRESH 487

  Fly   440 TK-GLYTLSLHTKVPQSHVKHYHIK--QNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKS 501
            .| |.|.||:::   ....:|:.|:  .|    .|..|......||.||::| .|:..:..:...
  Rat   488 GKPGEYVLSVYS---DGQRRHFIIQFVDN----LYRFEGTGFSNIPQLIDHH-FNTKQVITKKSG 544

  Fly   502 SPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSE--D 564
            .....|:|     ...||.::..::.|.|.||.|.||.|.:|..:.....|||..||....|  .
  Rat   545 VVLLNPIP-----KDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKI 604

  Fly   565 DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCI 629
            .|::|||::.:..|||:|:|.|||::.:|:||:.|.:..|..|::||:.:..|  .:..|:...:
  Rat   605 KFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDEL--KLKQLVRFSL 667

  Fly   630 QVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEV 694
            .|:.||.|||..|.|||||||||||||..|.:|::|||::|......|:|||..:.||||..||.
  Rat   668 DVAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEA 732

  Fly   695 LNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLC 759
            |||.|:||:||||::|:|:||.|:.|..||..:.|.:..|:|:||..:..|::|.:||:.:|..|
  Rat   733 LNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEIFTIMMKC 797

  Fly   760 WSHGPEERPAFRVLMDQLALVAQTLT 785
            |.:.||.||.|..|..:|..:.:.:|
  Rat   798 WDYKPENRPKFSDLHKELTAIKKKIT 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 3/8 (38%)
SH2_Tec_family 403..505 CDD:198188 33/119 (28%)
PTKc_Tec_like 521..778 CDD:173637 109/258 (42%)
FerNP_001382687.1 Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250 1..300
F-BAR_Fer 5..238 CDD:153370
SH2_Fps_family 454..539 CDD:198224 31/95 (33%)
Protein Kinases, catalytic domain 567..817 CDD:473864 109/251 (43%)
Blue background indicates that the domain is not in the aligned region.

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