Protein Alignment Btk and Zap70

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006244823.1
• Gene: Zap70 / 301348
• RGDID: 3983
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 561
• Identity: 172/561 - (30%)
• Similarity: 259/561 - (46%)
• Gaps: 117/561 - (20%)

  Fly   286 GGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGI-PTPGTPNSKAKDNSHFVKLVVA 349
            ||...|.|..|     ...:.|.|..|..| .....|.|.|: |.||.
  Rat    97 GGKAHCGPAEL-----CQFYSQDPDGLPCN-LRKPCNRPPGLEPQPGV----------------- 138

  Fly   350 LYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-DALGNVGYIPSNYVKPKALLGL---ERYEW 410
               |..:...           ::.|.....||:: |||...  |.|...:.:.|:..   ||..|
  Rat   139 ---FDCLRDA-----------MVRDYVRQTWKLEGDALEQA--IISQAPQVEKLIATTAHERMPW 187

  Fly   411 YVGDMSRQRAESLLKQGDK-EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE 474
            |...::|:.||..|..|.: :|.|::|....:|.|.|||   |....|.||.|.|:...:|.:.|
  Rat   188 YHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSL---VYGKTVYHYLISQDKAGKYCIPE 249

  Fly   475 KHCCETIPDLINYHRHNSGGLACRLK--------SSPCDRPV----PPTAGLSH----------- 516
            ....:|:..|:.|.:..:.||..|||        |:....|.    |.|....|
  Rat   250 GTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFTQPHRRIDTLNSDGY 314

  Fly   517 -------DKWEIHPMELMLME--------------------------ELGSGQFGVVRRGKWR-- 546
                   ||....||:..:.|                          |||.|.||.||:|.:|
  Rat   315 TPEPARLDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMR 379

  Fly   547 -GSIDTAVKMMKEGT--MSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLN 608
             ..||.|:|::|:.|  ..:|:.:.||::|.:|.:|.:|:|.||| :...:.:|.|....|.|..
  Rat   380 KKQIDVAIKVLKQSTEKADKDEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHK 443

  Fly   609 YL-RRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV 672
            :| .:.|:..:.|:..||.   ||:.||.|||..|::||||||||.|:.:.:..|::||||::.:
  Rat   444 FLIGKKEEIPVSNVAELLH---QVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 505

  Fly   673 -LDDQ-YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVER 735
             .||. ||:....|:|:||..||.:|:.:|||:||||:|||.|||.|:.|:.||.::|..||::.
  Rat   506 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDF 570

  Fly   736 VQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQ 776
            :::|..:|.|..|..|:|.:|..||.:..|:||.| |.::|
  Rat   571 IKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDF-VAVEQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	9/53 (17%)
		SH2_Tec_family	403..505	CDD:198188	34/113 (30%)
		PTKc_Tec_like	521..778	CDD:173637	107/290 (37%)
Zap70	XP_006244823.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191	12/43 (28%)
		SH2	176..280	CDD:472789	34/106 (32%)
		PTKc_Zap-70	352..620	CDD:270686	104/264 (39%)