Protein Alignment Btk and ABL2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 213/556 - (38%)
• Similarity: 302/556 - (54%)
• Gaps: 65/556 - (11%)

  Fly   233 GSSPAQNSTRSISPNSSTTNSQFSL--QHNSSGS-LGGGVGGGLGGGGSLGLGGGGGGGGSCTPT 294
            |||.|:.|.|...|...||.:.|::  ||:...| :..|..|...||.|              |.
Human    24 GSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSS--------------PE 74

  Fly   295 SL--------QPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALY 351
            :|        :||:.....:.|     ....||.|       |...||           |.||||
Human    75 ALHRPYGCDVEPQALNEAIRWS-----SKENLLGA-------TESDPN-----------LFVALY 116

  Fly   352 PFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMS 416
            .|.|.....||:.|..:..|:..:|...|....:....|::||||:.|  :..||::.||.|.:|
Human   117 DFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITP--VNSLEKHSWYHGPVS 179

  Fly   417 RQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET 480
            |..||.|| .....|.|:||:| |:.|..::||..   :..|.||.|...|..:.|::.:....|
Human   180 RSAAEYLL-SSLINGSFLVRESESSPGQLSISLRY---EGRVYHYRINTTADGKVYVTAESRFST 240

  Fly   481 IPDLINYHRHNSGGLACRL--KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRG 543
            :.:|:::|...:.||...|  .:..|::|........|||||:...::.:..:||.||:|.|..|
Human   241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVG 305

  Fly   544 KWRG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607
            .|:. |:..|||.:||.||..::|::||.||.:::|||||||.|||:...|.|||||||.:|:||
Human   306 VWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLL 370

  Fly   608 NYLR---RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA 669
            :|||   |.|.|.:    :||.|..|:|..|.|||:.|:|||||||||||||..:|||||||||:
Human   371 DYLRECNREEVTAV----VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLS 431

  Fly   670 RYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVE 734
            |.:..|.||:..|.||||||..||.|.|..||.||||||:|||:|||.|.|..||..:..::|.:
Human   432 RLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 496

  Fly   735 RVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            .:::|..:|:|:.|..::|::|:.||...|.:||:|
Human   497 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/52 (35%)
		SH2_Tec_family	403..505	CDD:198188	32/104 (31%)
		PTKc_Tec_like	521..778	CDD:173637	126/254 (50%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		9/22 (41%)
		CAP	2..106		26/107 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80		7/33 (21%)
		SH3_Abl	111..164	CDD:212784	18/52 (35%)
		SH2_ABL	169..262	CDD:198189	31/96 (32%)
		PTKc_Abl	281..543	CDD:270645	128/256 (50%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		13/23 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885