Protein Alignment Btk and T21G5.1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001355382.1
• Gene: T21G5.1 / 266839
• WormBaseID: WBGene00020659
• Length: 514
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 153/524 - (29%)
• Similarity: 235/524 - (44%)
• Gaps: 138/524 - (26%)

  Fly   311 LLNGNGTLL---------DANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKN 366
            :|.|||...         .||.||   ||..|..|.|:....|. ||.:.|
 Worm    26 VLPGNGITTGGSREGSKESANPPG---TPPPPEEKPKEPMVDVP-VVQITP-------------- 72

  Fly   367 AEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEG 431
                          ::|......|.||    :..|.|.|.    ||||...:|||.....|   |
 Worm    73 --------------EIKGCQFYHGIIP----RVDAELSLR----YVGDYLLRRAEPRENAG---G 112

  Fly   432 CFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYY---LSEKHCCETIPDLINYHRHNSG 493
            .|::          :|:..:....||.....|:.|:..|:   |.|    .|:.|||:.|
 Worm   113 QFLI----------ISVKREAGFVHVPISQDKEGAKQFYFMPTLKE----NTVLDLIDVH----- 158

  Fly   494 GLACRLKSSP-C-------DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW----- 545
             ||   ::.| |       .:||      ....|.|...:::|..::|||.||.|...:.
 Worm   159 -LA---RAQPVCVQWNVYLRKPV------LRATWIIPHEDVILYRKIGSGAFGEVFLARMVDPTS 213

  Fly   546 RGSIDTAVKMMK-EGTM-SEDDFIEEAKVMTK-LQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607
            ...:|.|||.:| |.|| ::..|::||::|.| .:|.::|.::|:.:.:.|:.|:.|...:|||:
 Worm   214 EYVLDCAVKKLKQEATMDAKLRFMKEARMMLKNYKHKHIVMIFGIATLNSPLLILMELCPNGSLI 278

  Fly   608 NYLRRHEKTLIGNMGLL--LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA- 669
            :|||:::    |.:.||  |....:.|.|:.|||:...||||:||||||:.::|.:|::|.|||
 Worm   279 SYLRKNK----GKVTLLEKLRFSAEASSGLAYLEKMECIHRDIAARNCLLSAKNEIKISDLGLAD 339

  Fly   670 ------RYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLK 728
                  .|.||         |.||||..||::....:|.|||:||:|:::||||..|..||..|.
 Worm   340 DKGMVIDYSLD---------KLPIKWLAPEIMQDKVYSLKSDIWAFGIMIWEIFAEGDEPYPGLN 395

  Fly   729 NTEVVERVQRGIILEK----PKSCAKEIYDVMKLCWSHGPEER-------PAFRVLMDQL--ALV 780
            ||:...::   ::|:.    |.....|:..|:..||...|:.|       .|.::|.:..  .|.
 Worm   396 NTQARAKI---VVLDYRMKFPDEAPTELVQVIDTCWKKDPDMRQTMVLHSSALQLLYENKLPLLF 457

  Fly   781 AQTL 784
            |||:
 Worm   458 AQTI 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	7/52 (13%)
		SH2_Tec_family	403..505	CDD:198188	29/112 (26%)
		PTKc_Tec_like	521..778	CDD:173637	95/286 (33%)
T21G5.1	NP_001355382.1	SH2_Fps_family	72..165	CDD:198224	33/154 (21%)
		STYKc	189..438	CDD:214568	92/264 (35%)