Protein Alignment Btk and Hck

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_037317.2
• Gene: Hck / 25734
• RGDID: 2785
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 607
• Identity: 211/607 - (34%)
• Similarity: 308/607 - (50%)
• Gaps: 110/607 - (18%)

  Fly   180 RQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRT-TFGCRAAAHWREANNNPSNGSSPAQNSTRS 243
            |..|||          ||        |.:|..|. ..||..:...||       ||..::
  Rat     4 RSSCED----------PG--------CPRGEGRVPRMGCVKSRFLRE-------GSKASK----- 38

  Fly   244 ISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQS 308
            |.||:           |..|.:                         ..|....|:      |..
  Rat    39 IEPNA-----------NQKGPV-------------------------YVPDPTSPK------KLG 61

  Fly   309 PTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVID 373
            |..:|        ::|.|: ..|:.::          :|||||.::||...|||.:|..:..|::
  Rat    62 PNSIN--------SLPPGV-VEGSEDT----------IVVALYDYEAIHREDLSFQKGDQMVVLE 107

  Fly   374 DSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVR 436
            :|.| |||.:. |....||||||||  ..:..||..||:...:||:.|| .||..|:..|.|::|
  Rat   108 ESGE-WWKARSLATKKEGYIPSNYV--ARVNSLETEEWFFKGISRKDAERHLLAPGNMLGSFMIR 169

  Fly   437 KS-STKGLYTLSLHTKVPQ--SHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACR 498
            .| :|||.|:||:....||  ..||||.|:......:|:|.:....::.:|:.:::....|| |:
  Rat   170 DSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHYKKGKDGL-CQ 233

  Fly   499 LKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSE 563
            ..|.||..| .|......|.|||....|.:.::||:||||.|....:......|||.||.|:||.
  Rat   234 KLSVPCVSP-KPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSV 297

  Fly   564 DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGN---MGLLL 625
            :.|:.||.:|..|||..||:|:.|.|: .||:||||:|..||||::|:..|    |:   :..|:
  Rat   298 EAFLAEANLMKTLQHDKLVKLHAVVSQ-EPIFIVTEFMAKGSLLDFLKSEE----GSKQPLPKLI 357

  Fly   626 DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWA 690
            |...|:|:||.::|:.|||||||.|.|.||.:..|.|:|||||||.:.|::||:..|.||||||.
  Rat   358 DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWT 422

  Fly   691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDV 755
            .||.:|:..|:.|||||::|:|:.||.|.|::||..:.|.||:..::.|..:.:|.:|.:|:|.:
  Rat   423 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSI 487

  Fly   756 MKLCWSHGPEERPAFRVLMDQL 777
            |..||.:.|||||.|..:...|
  Rat   488 MIRCWKNRPEERPTFEYIQSVL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	11/42 (26%)
		SH3_Tec_like	346..399	CDD:212702	26/53 (49%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	115/260 (44%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..71		11/90 (12%)
		SH3	80..135	CDD:473055	26/57 (46%)
		SH2_Src_HCK	138..241	CDD:198226	36/103 (35%)
		Protein Kinases, catalytic domain	252..522	CDD:473864	117/263 (44%)