DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and Hck

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	211/607 - (34%)
Similarity:	308/607 - (50%)	Gaps:	110/607 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 RQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRT-TFGCRAAAHWREANNNPSNGSSPAQNSTRS 243
            |..|||          ||        |.:|..|. ..||..:...||       ||..::
  Rat     4 RSSCED----------PG--------CPRGEGRVPRMGCVKSRFLRE-------GSKASK----- 38

  Fly   244 ISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQS 308
            |.||:           |..|.:                         ..|....|:      |..
  Rat    39 IEPNA-----------NQKGPV-------------------------YVPDPTSPK------KLG 61

  Fly   309 PTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVID 373
            |..:|        ::|.|: ..|:.::          :|||||.::||...|||.:|..:..|::
  Rat    62 PNSIN--------SLPPGV-VEGSEDT----------IVVALYDYEAIHREDLSFQKGDQMVVLE 107

  Fly   374 DSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVR 436
            :|.| |||.:. |....||||||||  ..:..||..||:...:||:.|| .||..|:..|.|::|
  Rat   108 ESGE-WWKARSLATKKEGYIPSNYV--ARVNSLETEEWFFKGISRKDAERHLLAPGNMLGSFMIR 169

  Fly   437 KS-STKGLYTLSLHTKVPQ--SHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACR 498
            .| :|||.|:||:....||  ..||||.|:......:|:|.:....::.:|:.:::....|| |:
  Rat   170 DSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHYKKGKDGL-CQ 233

  Fly   499 LKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSE 563
            ..|.||..| .|......|.|||....|.:.::||:||||.|....:......|||.||.|:||.
  Rat   234 KLSVPCVSP-KPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSV 297

  Fly   564 DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGN---MGLLL 625
            :.|:.||.:|..|||..||:|:.|.|: .||:||||:|..||||::|:..|    |:   :..|:
  Rat   298 EAFLAEANLMKTLQHDKLVKLHAVVSQ-EPIFIVTEFMAKGSLLDFLKSEE----GSKQPLPKLI 357

  Fly   626 DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWA 690
            |...|:|:||.::|:.|||||||.|.|.||.:..|.|:|||||||.:.|::||:..|.||||||.
  Rat   358 DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWT 422

  Fly   691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDV 755
            .||.:|:..|:.|||||::|:|:.||.|.|::||..:.|.||:..::.|..:.:|.:|.:|:|.:
  Rat   423 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSI 487

  Fly   756 MKLCWSHGPEERPAFRVLMDQL 777
            |..||.:.|||||.|..:...|
  Rat   488 MIRCWKNRPEERPTFEYIQSVL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	11/42 (26%)
		SH3_Tec_like	346..399	CDD:212702	26/53 (49%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	115/260 (44%)
		Pkinase_Tyr	526..777	CDD:285015	113/253 (45%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71		11/90 (12%)
		SH3	80..135	CDD:302595	26/57 (46%)
		SH2_Src_HCK	138..241	CDD:198226	36/103 (35%)
		PKc_like	252..522	CDD:304357	117/263 (44%)
		Pkinase_Tyr	260..509	CDD:285015	113/253 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820