DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk29A and Map3k12

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_037187.1 Gene:Map3k12 / 25579 RGDID:3988 Length:888 Species:Rattus norvegicus


Alignment Length:338 Identity:100/338 - (29%)
Similarity:166/338 - (49%) Gaps:56/338 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 LINYHRHNSGG---------------------LACRLKSS------PCDRPVPPTAGLSH----- 516
            ::..|..::||                     |.|:..|.      .|.|||....|.::     
  Rat    80 VLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHK 144

  Fly   517 ----DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
                |.||:...|::.::.:|||..|.|..|::.|. :.|||.:::  :.|.|.    |.:.||:
  Rat   145 QQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--LKETDI----KHLRKLK 202

  Fly   578 HPNLVQLYGVCSKHRPIY-IVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERH 641
            |||::...|||:: .|.| |:.|:...|.|...||.....   ...||:|..:.::.||.||..|
  Rat   203 HPNIITFKGVCTQ-APCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 263

  Fly   642 NYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYT--SSGGTKFPIKWAPPEVLNYTRFSSKS 704
            ..|||||.:.|.|:..::|||::|||.:: .|.|:.|  |..||   :.|..|||:.....|.|.
  Rat   264 KIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKV 324

  Fly   705 DVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV-QRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            |:|::||::||:.| |::||..:.::.::..| ...:.|..|.||......:::.||:..|..||
  Rat   325 DIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRP 388

  Fly   769 AFRVLMDQLALVA 781
            :||.::..|.:.:
  Rat   389 SFRQILLHLDIAS 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 6/47 (13%)
PTKc_Tec_like 521..778 CDD:173637 85/260 (33%)
Pkinase_Tyr 526..777 CDD:285015 84/254 (33%)
Map3k12NP_037187.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..104 3/23 (13%)
STKc_MAP3K12_13 164..400 CDD:270961 85/251 (34%)
TyrKc 165..397 CDD:197581 84/247 (34%)
Leucine-zipper 1 423..444
Leucine-zipper 2 476..497
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..620
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..731
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 743..888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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