DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Ros1

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_038954373.1 Gene:Ros1 / 25346 RGDID:3591 Length:2339 Species:Rattus norvegicus


Alignment Length:883 Identity:225/883 - (25%)
Similarity:357/883 - (40%) Gaps:197/883 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 KSSSSLRSSSK--------SFQAKMDLMSERLYDVVKSG---SMVKRAQNKK---RFTPVNYKHR 66
            |.|.::.|..|        ::.:.:....::.|..|.|.   :.:..|.|..   :..||.....
  Rat  1406 KGSGAILSQVKAPRSKHILAYSSALQPFPDKAYLSVASNMVEASILNATNTSLILKLPPVKTNLT 1470

  Fly    67 WFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASA 131
            |..:|..|.:|. |..:|..|.........:...:|.....||..||:.  |..|:......:..
  Rat  1471 WHGITTPTSTYL-VYYMEANRANSSDRKHNMLESQENVARIEGLQPFST--YVIQIAVKNYYSDP 1532

  Fly   132 NSHQLENGNGGGSGVGIEGQ-QSGRAVPQYTLYVIA------------------NSEKERSEWIR 177
            ..|.       ..|..|:|: :||  ||....::.|                  |..||...:..
  Rat  1533 LEHL-------SLGKEIQGKTKSG--VPGAVCHINATVLSDTSLLVFWTESHKPNGPKELVRYQL 1588

  Fly   178 AIRQVCEDSNTPKSYRYHPGL--------WSGKKWSCCKGLSRTTFGCRAAAHW-REAN------ 227
            .:..:.....||......|..        .||.:....|.|:     |.:...| .|::      
  Rat  1589 VMSYLAPIPETPLRQDEFPSARLSLLVTKLSGGQQYVLKILA-----CHSEEMWCTESHPVSVNM 1648

  Fly   228 -NNPSNGSSPAQNSTRSI----SP-NSSTTNSQFSLQ--------HNSSGSLGGGVGGGLGGGGS 278
             :.|...|:....:|..:    :| |::.|...|.||        |..:....|.|         
  Rat  1649 FDTPEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKWKYSEFYHVKASCSQGPV--------- 1704

  Fly   279 LGLGGGGGGGGSCTPTSLQPQSS--------LTTFKQSPTLLNGNGTLLDANMPGGIP--TPGTP 333
                      ..|...:|||.:.        .||.:.|.::.....|........|||  ..|:.
  Rat  1705 ----------YVCNIANLQPYTPYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSK 1759

  Fly   334 NS----KAKDNSHFVKLVVALYPFKAI--EGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGY- 391
            ||    ||:||.:.: :...|...|:|  :..|.||...|.:.. ..|....|:.|:..|...: 
  Rat  1760 NSIQWEKAEDNGNRL-MYYTLEVRKSISNDSRDQSLRWTAVFNG-SCSSICTWRSKNLKGTFQFR 1822

  Fly   392 -IPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSS-----TKGLYTLSLHT 450
             :.||      .:|...|.....|:      :|::.|     |.:.::|     ..|::   |..
  Rat  1823 AVASN------AIGFGEYSEISEDI------TLVEDG-----FWITETSFILTIIVGIF---LVA 1867

  Fly   451 KVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS 515
            .||.:.|.|..:|.:...:..||          ::|.:......|          |.:....||:
  Rat  1868 TVPLTFVWHRSLKNHKATKEGLS----------VLNDNDQELAEL----------RGLAAGVGLA 1912

  Fly   516 HDKWEIHPM---------------ELMLMEELGSGQFGVVRR-------GKWRGSIDTAVKMMKE 558
            :..:.:|.:               :|.|...||||.||.|..       |:..|.|..|||.:|:
  Rat  1913 NACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVDILGRGSGEIKVAVKTLKK 1977

  Fly   559 GTMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG-- 619
            |:..::  :|::||.:|:|..|||:::..|||....|.||:.|.|:.|.||:|||:...|.:.  
  Rat  1978 GSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLSEPQYIILELMEGGDLLSYLRKARGTTLSGP 2042

  Fly   620 --NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG-----SENVVKVADFGLARYVL-DDQ 676
              .:..|:::|:.:|||..|||:.::||||||||||||.     |..|||:.||||||.:. .|.
  Rat  2043 LLTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKHDY 2107

  Fly   677 YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII 741
            |...|....|::|..||.|....|:|:||||::|:|:|||.|.|..||....|.:|:..||.|..
  Rat  2108 YRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGR 2172

  Fly   742 LEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLAL 779
            ||.|::|..:::::|..||:..|::||.|..:.|||.|
  Rat  2173 LEPPRNCPDDLWNLMFRCWAQEPDQRPTFYNIQDQLQL 2210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944 39/210 (19%)
SH3_Tec_like 346..399 CDD:212702 13/56 (23%)
SH2_Tec_family 403..505 CDD:198188 18/106 (17%)
PTKc_Tec_like 521..778 CDD:173637 112/290 (39%)
Ros1XP_038954373.1 FN3 <99..>296 CDD:442628
FN3 567..663 CDD:238020
FN3 1036..1142 CDD:238020
FN3 1449..1527 CDD:214495 18/80 (23%)
FN3 1551..1630 CDD:238020 11/78 (14%)
FN3 1650..1741 CDD:238020 19/109 (17%)
FN3 1746..1839 CDD:238020 25/100 (25%)
PTKc_c-ros 1948..2209 CDD:270640 105/260 (40%)
Blue background indicates that the domain is not in the aligned region.

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