DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Fyn

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_006256584.1	Gene:	Fyn / 25150	RGDID:	2641	Length:	575	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	213/538 - (39%)
Similarity:	301/538 - (55%)	Gaps:	46/538 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 VGGGLGG--------------------GGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLN 313
            |||.||.                    .|||....|...|...||.. .|...:|:.   |...|
  Rat    30 VGGNLGAWIMGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQH-YPSFGVTSI---PNYNN 90

  Fly   314 -----GNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVID 373
                 |.|    ..:.||:.:.....:........|.|.||||.::|....|||..|..::::::
  Rat    91 FHAAGGQG----LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILN 151

  Fly   374 DSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVR 436
            .|:..||:.:. ..|..||||||||.|  :..::..|||.|.:.|:.|| .||..|:..|.|::|
  Rat   152 SSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIR 214

  Fly   437 KS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACR 498
            :| :|||.|:||:.  ..:...|||||.|::.....||::.:...||:..|:.::...:.||.||
  Rat   215 ESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCR 279

  Fly   499 LKSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGT 560
            | ..||.:.:|....||   .|.|||....|.|::.||:||||.|..|.|.|:...|:|.:|.||
  Rat   280 L-VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGT 343

  Fly   561 MSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLL 625
            ||.:.|:|||::|.||:|..|||||.|.|: .|||||||||..||||::|:..|...: .:..|:
  Rat   344 MSPESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRAL-KLPNLV 406

  Fly   626 DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWA 690
            ||..||:.||.|:||.|||||||.:.|.|||:..:.|:|||||||.:.|::||:..|.||||||.
  Rat   407 DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 471

  Fly   691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDV 755
            .||...|.||:.|||||::|:|:.|:.|.|::||..:.|.||:|:|:||..:..|:.|...::::
  Rat   472 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHEL 536

  Fly   756 MKLCWSHGPEERPAFRVL 773
            |..||...|||||.|..|
  Rat   537 MIHCWKKDPEERPTFEYL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	37/105 (35%)
		PTKc_Tec_like	521..778	CDD:173637	125/253 (49%)
		Pkinase_Tyr	526..777	CDD:285015	124/248 (50%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939	22/54 (41%)
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	36/100 (36%)
		PTKc_Fyn	299..572	CDD:270655	128/258 (50%)
		Pkinase_Tyr	309..558	CDD:285015	124/248 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820