Protein Alignment Btk and Fgfr2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_036844.1
• Gene: Fgfr2 / 25022
• RGDID: 2611
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 321
• Identity: 112/321 - (34%)
• Similarity: 170/321 - (52%)
• Gaps: 44/321 - (13%)

  Fly   501 SSPCDRPVPPTAGLSH------DKWEIHPMELMLMEELGSGQFGVV--------RRGKWRGSIDT 551
            ||..|.|:  .||:|.      .|||....:|.|.:.||.|.||.|        .:.:.:.::..
  Rat   472 SSTADTPM--LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTV 534

  Fly   552 AVKMMKEGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRH 613
            ||||:|:....:|  |.:.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..|||..
  Rat   535 AVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 599

  Fly   614 EKTLIGNMGL------------------LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENV 660
            ...     |:                  |:....|:::||.||.....|||||||||.||...||
  Rat   600 RPP-----GMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 659

  Fly   661 VKVADFGLARYVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            :|:|||||||.:.: |.|..:...:.|:||..||.|....::.:||||::|||||||||.|..||
  Rat   660 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 724

  Fly   725 GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLT 785
            ..:...|:.:.::.|..::||.:|..|:|.:|:.||...|.:||.|:.|::.|..:. |||
  Rat   725 PGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-TLT 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	2/3 (67%)
		PTKc_Tec_like	521..778	CDD:173637	98/286 (34%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:472250
		Ig strand B	77..81	CDD:409362
		Ig strand C	88..92	CDD:409362
		Ig strand E	109..113	CDD:409362
		Ig strand F	123..128	CDD:409362
		Ig strand G	136..139	CDD:409362
		IgI_2_FGFR	173..267	CDD:409443
		Ig strand A	173..176	CDD:409443
		Ig strand A'	184..189	CDD:409443
		Ig strand B	193..201	CDD:409443
		Ig strand C	207..212	CDD:409443
		Ig strand C'	215..217	CDD:409443
		Ig strand D	226..229	CDD:409443
		Ig strand E	233..238	CDD:409443
		Ig strand F	247..254	CDD:409443
		Ig strand G	257..267	CDD:409443
		Ig	275..377	CDD:472250
		Ig strand B	293..297	CDD:409353
		Ig strand C	306..310	CDD:409353
		Ig strand E	342..346	CDD:409353
		Ig strand F	356..361	CDD:409353
		Ig strand G	369..372	CDD:409353
		PTKc_FGFR2	476..788	CDD:270679	110/317 (35%)