DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and ABL1

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_009297.2	Gene:	ABL1 / 25	HGNCID:	76	Length:	1149	Species:	Homo sapiens

Alignment Length:	502	Identity:	192/502 - (38%)
Similarity:	279/502 - (55%)	Gaps:	49/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 GGGSC------------TPTSLQPQ--SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
            ||..|            ..:..:||  |....:.....||.|             |:...||
Human    35 GGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAG-------------PSENDPN--- 83

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKAL 402
                    |.||||.|.|.....||:.|..:..|:..:....|.........|::||||:.|  :
Human    84 --------LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITP--V 138

  Fly   403 LGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNA 466
            ..||::.||.|.:||..||.||..| ..|.|:||:| |:.|..::||..   :..|.||.|...:
Human   139 NSLEKHSWYHGPVSRNAAEYLLSSG-INGSFLVRESESSPGQRSISLRY---EGRVYHYRINTAS 199

  Fly   467 RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS--HDKWEIHPMELMLM 529
            ..:.|:|.:....|:.:|:::|...:.||...|......|..|...|:|  :||||:...::.:.
Human   200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMK 264

  Fly   530 EELGSGQFGVVRRGKWRG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRP 593
            .:||.||:|.|..|.|:. |:..|||.:||.||..::|::||.||.:::|||||||.|||::..|
Human   265 HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP 329

  Fly   594 IYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSE 658
            .||:||:|.:|:||:|||...:..: |..:||.|..|:|..|.|||:.|:|||||||||||||..
Human   330 FYIITEFMTYGNLLDYLRECNRQEV-NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 393

  Fly   659 NVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMP 723
            ::||||||||:|.:..|.||:..|.||||||..||.|.|.:||.||||||:|||:|||.|.|..|
Human   394 HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 458

  Fly   724 YGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            |..:..::|.|.:::...:|:|:.|.:::|::|:.||...|.:||:|
Human   459 YPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/52 (33%)
		SH2_Tec_family	403..505	CDD:198188	33/102 (32%)
		PTKc_Tec_like	521..778	CDD:173637	121/251 (48%)
		Pkinase_Tyr	526..777	CDD:285015	121/246 (49%)
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	17/52 (33%)
		SH2_ABL	142..235	CDD:198189	32/96 (33%)
		PTKc_Abl	254..516	CDD:270645	123/253 (49%)
		Pkinase_Tyr	261..512	CDD:285015	121/246 (49%)
		FABD	1025..1149	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910