Protein Alignment Btk and Yes1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001385513.1
• Gene: Yes1 / 24884
• RGDID: 3977
• Length: 541
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 212/573 - (36%)
• Similarity: 317/573 - (55%)
• Gaps: 61/573 - (10%)

  Fly   216 GCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLG 280
            ||..:    :.|.:|:...:| :|.|..:    :|:...:.::| ::.:......|......||.
  Rat     2 GCIKS----KENKSPAIKYTP-ENPTEPV----NTSAGHYGVEH-ATAATTSSTKGASANFNSLS 56

  Fly   281 LG--GGGGG----GGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKD 339
            :.  ||..|    ||:.:..|:.|.|       .||.|.|.
  Rat    57 MTPFGGSSGVTPFGGASSSFSVVPSS-------YPTSLTGG------------------------ 90

  Fly   340 NSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALL 403
                |.:.||||.::|....|||.:|...:::|::::..||:.:. |.|..||||||||.|...:
  Rat    91 ----VTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSI 151

  Fly   404 GLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQ 464
            ..|  |||.|.|.|:.||. ||..|::.|.|:||:| :|||.|:||:.  .:|...:||||.|::
  Rat   152 QAE--EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRK 214

  Fly   465 NARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLM 529
            .....||::.:...:|:..|:.::..::.|| |...::.|....|.|.||:.|.|||....|.|.
  Rat   215 LDNGGYYITTRAQFDTLQKLVKHYTEHADGL-CHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLE 278

  Fly   530 EELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPI 594
            .:||.|.||.|..|.|.|:...|:|.:|.|||..:.|::||::|.||:|..||.||.|.|: .||
  Rat   279 VKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPI 342

  Fly   595 YIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN 659
            |||||:|..||||::|:..:...: .:..|:||..|::.||.|:||.|||||||.|.|.|||...
  Rat   343 YIVTEFMSKGSLLDFLKEGDGKYL-KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENL 406

  Fly   660 VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            |.|:|||||||.:.|::||:..|.||||||..||...|.||:.|||||::|:|..|:.|.|::||
  Rat   407 VCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPY 471

  Fly   725 GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ..:.|.||:|:|:||..:..|:.|.:.::::|.|||...|:|||.|..:...|
  Rat   472 PGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	2/5 (40%)
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	120/257 (47%)
Yes1	NP_001385513.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		8/35 (23%)
		SH3_Yes	92..149	CDD:212940	23/56 (41%)
		SH2_Src_family	152..251	CDD:199827	36/101 (36%)
		PTKc_Yes	262..540	CDD:270654	125/265 (47%)