Protein Alignment Btk and ros1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_073784362.1
• Gene: ros1 / 245951
• ZFINID: ZDB-GENE-020506-1
• Length: 1408
• Species: Danio rerio
• Alignment Length: 560
• Identity: 158/560 - (28%)
• Similarity: 242/560 - (43%)
• Gaps: 144/560 - (25%)

  Fly   306 KQSPTLLNGNGTLLDAN--------MPGGIPTPGT--PNSKAKDNSHFVKLVVALYPFKAIEGGD 360
            :.:..|::.|.||...:        :|.|..:|..  |.:.:|
Zfish   826 QNNSVLMSSNNTLTAFSVVQKMLKPLPDGFVSPPVVIPPAVSK---------------------- 868

  Fly   361 LSLEKNAEYEVIDDSQEHW-------------------WKVKDALGNVGYIPSNYVKP-----KA 401
            :.|..||.:     .|.||                   ||..|.|.|:  .|:.|..|     :.
Zfish   869 IVLVGNASF-----FQIHWEPSSVDYGTVFYCVVSKEVWKNLDPLPNM--FPTRYCHPVNTFTET 926

  Fly   402 LLGLERYE--------------WYVGDMSRQRAESLL----KQGDKEGCFVVRKSSTK---GLYT 445
            ::.:.|::              |..|    :..|::|    ...|.:...::...|..   .|..
Zfish   927 VINVTRFKPGAELNITITPFSYWGKG----KSTETILITPAGTSDTDKTLIIAIVSVAVGVTLII 987

  Fly   446 LSLHTKVPQSHVK---HYHIKQNARCEYYLSEKHCCETIPDL-INYHRHNSGGL-----ACRLKS 501
            |.|...:.|.|.|   |...||.:..:.:          ||: :.|.|    ||     .|...|
Zfish   988 LILAVVIWQRHHKKKDHGKAKQPSSVQIH----------PDVELEYVR----GLVGLENGCFAIS 1038

  Fly   502 SPCDRPVPPTAGLSHDKWEIHPME-LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKE---GTMS 562
            :     .|..|.:  :...:.|.: |.|...||||.||.|..|...||....|:..::   .|:.
Zfish  1039 N-----TPSRAEI--ESLPVFPRDCLKLQRLLGSGAFGEVYEGVTVGSQINGVEPERKVAIKTLQ 1096

  Fly   563 ED-------DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR------RHE 614
            :|       :|::||.:|::..|||:::|.|||..:.|.|::.|.|:.|.|.:|||      .|:
Zfish  1097 KDASDYEKTEFLKEAHLMSQFNHPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGARPTNNHK 1161

  Fly   615 KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG------SENVVKVADFGLARYVL 673
            :.|  ::..|||:.:..:.|..||||.:::|||:|||||||.      .|.|||:.||||||.|.
Zfish  1162 ELL--SLSSLLDISLDAATGCAYLERMHFVHRDIAARNCLVSVRTYTDPERVVKIGDFGLARDVY 1224

  Fly   674 -DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ 737
             :|.|...|....|::|..||.|....|:..|||||:|||:|||.|.||:||....|.||:..:.
Zfish  1225 KNDYYRKKGEGLLPVRWMSPESLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPTYTNHEVLSYIS 1289

  Fly   738 RGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            .|..|..|..|.:.:|::|..|||..|.:||.|:.|.:.:
Zfish  1290 TGGRLSSPAGCPQRLYNLMMSCWSKQPADRPNFQFLEETM 1329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	13/71 (18%)
		SH2_Tec_family	403..505	CDD:198188	24/131 (18%)
		PTKc_Tec_like	521..778	CDD:173637	109/281 (39%)
ros1	XP_073784362.1	None