Protein Alignment Btk and ptk2bb

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001410482.1
• Gene: ptk2bb / 245950
• ZFINID: ZDB-GENE-020507-1
• Length: 1004
• Species: Danio rerio
• Alignment Length: 300
• Identity: 109/300 - (36%)
• Similarity: 173/300 - (57%)
• Gaps: 19/300 - (6%)

  Fly   489 RHNSGGLACRLKSSPCDRPVPPT-AGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR----GS 548
            |:::..:.|.:   |.::|.||. .|||.       .::.|...||.|.||.|..|.::    ..
Zfish   389 RYSNSDIYCEI---PDEKPPPPAKVGLSR-------KDISLKRMLGEGFFGEVHEGVYQKKNGEK 443

  Fly   549 IDTAVKMMKEGTMS-EDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRR 612
            ::.|||..||.... .:.|:.||.:|..|.||::|:|.||..:. |::||.|..:.|.|..||.:
Zfish   444 VNVAVKTCKECAPDIREKFVGEAVIMKNLDHPHIVRLIGVIEED-PVWIVMELCQQGELGKYLTK 507

  Fly   613 HEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQY 677
            ::::|. ::.|:| ..:|:.|.:.||:..|.:|||:|.||.||.:...||:.||||:||:.|::|
Zfish   508 NQQSLT-SVTLVL-FSLQLCKALVYLQGMNMVHRDIAVRNVLVATPECVKLGDFGLSRYIEDEEY 570

  Fly   678 TSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIIL 742
            ..:..|:.||||..||.:|:.||::.||||.:.|.:|||...||.|:..|.|.:|:.::::|..|
Zfish   571 YKASVTRLPIKWMAPESINFRRFTAASDVWMFAVCVWEIMNRGKQPFHWLDNRDVINQLEQGNRL 635

  Fly   743 EKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            .||:.|...:|.:|..|||:.|.|||.|..|...::.|.|
Zfish   636 PKPEQCPPALYSLMTRCWSYDPRERPTFTELACNISDVHQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	3/15 (20%)
		PTKc_Tec_like	521..778	CDD:173637	98/261 (38%)
ptk2bb	NP_001410482.1	FERM_N_2	36..133	CDD:436229
		B41	38..261	CDD:214604
		FERM_C_FAK1	257..364	CDD:270011
		PTKc_FAK	410..678	CDD:133187	102/275 (37%)
		Focal_AT	860..989	CDD:460992