Protein Alignment Btk and Jak2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_113702.1
• Gene: Jak2 / 24514
• RGDID: 2939
• Length: 1132
• Species: Rattus norvegicus
• Alignment Length: 290
• Identity: 98/290 - (33%)
• Similarity: 155/290 - (53%)
• Gaps: 32/290 - (11%)

  Fly   517 DKWEIHPMELMLMEELGSGQFGVVRRGKW------RGSIDTAVKMMKEGTMSE-DDFIEEAKVMT 574
            |..:.....|..:::||.|.||.|...::      .|.: .|||.::..|... .||..|.:::.
  Rat   840 DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTEEHLRDFEREIEILK 903

  Fly   575 KLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTY 637
            .|||.|:|:..|||  :..|.:.::.||:.:|||.:||::|::.:  :...||....|:.|||.|
  Rat   904 SLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERI--DHKKLLQYTSQICKGMEY 966

  Fly   638 LERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRF 700
            |....|||||||.||.||.:||.||:.||||.:.:..|:  |......:.||.|..||.|..::|
  Rat   967 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKF 1031

  Fly   701 SSKSDVWAYGVLMWEIFT---------------CGKMPYGRLKNTEVVERVQRGIILEKPKSCAK 750
            |..||||::||:::|:||               .|....|::....::|.::....|.:|:.|..
  Rat  1032 SVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPD 1096

  Fly   751 EIYDVMKLCWSHGPEERPAFRVL---MDQL 777
            |||.:|..||::...:||:||.|   :||:
  Rat  1097 EIYVIMTECWNNNVNQRPSFRDLSLRVDQI 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	97/286 (34%)
Jak2	NP_113702.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		FERM_F1	39..134	CDD:465733
		FERM_F2	143..261	CDD:436450
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663
		PTKc_Jak2_rpt2	844..1127	CDD:271107	97/286 (34%)