DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Map3k21

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_663583.2 Gene:Map3k21 / 234878 MGIID:2385307 Length:1002 Species:Mus musculus


Alignment Length:506 Identity:123/506 - (24%)
Similarity:192/506 - (37%) Gaps:163/506 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 MPGGIPTPGTPNSKAKDNSHFVK--LVVALYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWW 380
            :|....|..||.|.|:|:|....  :..|||.::|....:|||.:....||:.     ...|.||
Mouse     3 LPVAEGTADTPLSPARDDSGSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWW 67

  Fly   381 KVKDALGNV----GYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTK 441
                 .|.|    |..|::||.|                                          
Mouse    68 -----AGQVQRRLGIFPASYVAP------------------------------------------ 85

  Fly   442 GLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDR 506
                                                |..:|.                .:.|..|
Mouse    86 ------------------------------------CGPVPP----------------PAPPPPR 98

  Fly   507 PVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-----EGTMSEDDF 566
            |..|.    |..:|    .|.|.|.:|:|.||.|.|..|:|. :.|||..:     :...:.:..
Mouse    99 PCSPV----HVDFE----RLELKELIGAGGFGQVYRATWQGQ-EVAVKAARRDPEQDAAAAAESV 154

  Fly   567 IEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL------------RRHEKTLIG 619
            ..||::...|:|||::||.|||.:...:.:|.|:.:.|:|...|            ||..:.   
Mouse   155 RREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRI--- 216

  Fly   620 NMGLLLDMCIQVSKGMTYLERHNYI---HRDLAARNCLVGSE--------NVVKVADFGLARYVL 673
            ...:|::..:|:::||.||.....:   ||||.:.|.|:..:        ..:|:.||||||...
Mouse   217 PPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH 281

  Fly   674 DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQR 738
            .....|:.||   ..|..|||:..:.||..||:|:||||:||:.| |::||..:....|.    .
Mouse   282 RTTRMSAAGT---YAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVA----Y 338

  Fly   739 GIILEK-----PKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 784
            |:.:.|     |.:|.:....:||.||...|..||:|.:::.||..:.:.:
Mouse   339 GVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAV 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 18/61 (30%)
SH2_Tec_family 403..505 CDD:198188 3/101 (3%)
PTKc_Tec_like 521..778 CDD:173637 87/289 (30%)
Map3k21NP_663583.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 8/22 (36%)
SH3 28..82 CDD:473055 16/58 (28%)
Protein Kinases, catalytic domain 115..385 CDD:473864 85/281 (30%)
Leucine-zipper 1 409..430
Leucine-zipper 2 444..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..531
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..604
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 797..823
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..899
Blue background indicates that the domain is not in the aligned region.

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