Protein Alignment Btk and Zap70

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001276695.1
• Gene: Zap70 / 22637
• MGIID: 99613
• Length: 642
• Species: Mus musculus
• Alignment Length: 559
• Identity: 171/559 - (30%)
• Similarity: 256/559 - (45%)
• Gaps: 120/559 - (21%)

  Fly   286 GGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGI-PTPGTPNSKAKDNSHFVKLVVA 349
            ||...|.|..|     ...:.|.|..|..| .....|.|.|: |.||.
Mouse    97 GGKAHCGPAEL-----CQFYSQDPDGLPCN-LRKPCNRPPGLEPQPGV----------------- 138

  Fly   350 LYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-DALGNVGYIPSNYVKPKALLGL---ERYEW 410
               |..:...           ::.|.....||:: |||...  |.|...:.:.|:..   ||..|
Mouse   139 ---FDCLRDA-----------MVRDYVRQTWKLEGDALEQA--IISQAPQVEKLIATTAHERMPW 187

  Fly   411 YVGDMSRQRAESLLKQGDK-EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE 474
            |...::|:.||..|..|.: :|.|::|....:|.|.|||   |....|.||.|.|:...:|.:.|
Mouse   188 YHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSL---VYGKTVYHYLISQDKAGKYCIPE 249

  Fly   475 KHCCETIPDLINYHRHNSGGLACRLK------------------------SSPCDR--------- 506
            ....:|:..|:.|.:..:.||..|||                        :.|..|
Mouse   250 GTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGY 314

  Fly   507 -PVPPTAGLSHDKWEIHPMELMLME--------------------------ELGSGQFGVVRRGK 544
             |.|.....|.||....||:..:.|                          |||.|.||.||:|.
Mouse   315 TPEPARLASSTDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGV 379

  Fly   545 WR---GSIDTAVKMMKEGT--MSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHG 604
            :|   ..||.|:|::|:||  ..:|:.:.||::|.:|.:|.:|:|.||| :...:.:|.|....|
Mouse   380 YRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGG 443

  Fly   605 SLLNY-LRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGL 668
            .|..: |.:.|:..:.|:..||.   ||:.||.|||..|::||||||||.|:.:.:..|::||||
Mouse   444 PLHKFLLGKKEEIPVSNVAELLH---QVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 505

  Fly   669 ARYV-LDDQ-YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTE 731
            ::.: .||. ||:....|:|:||..||.:|:.:|||:||||:|||.|||.|:.|:.||.::|..|
Mouse   506 SKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPE 570

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            |::.:::|..:|.|..|..|:|.:|..||.:..|:||.|
Mouse   571 VLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDF 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	9/53 (17%)
		SH2_Tec_family	403..505	CDD:198188	34/129 (26%)
		PTKc_Tec_like	521..778	CDD:173637	106/284 (37%)
Zap70	NP_001276695.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191	12/43 (28%)
		SH2	176..280	CDD:472789	34/106 (32%)
		PTKc_Zap-70	356..624	CDD:270686	103/258 (40%)