Protein Alignment Btk and FGFR2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_075259.4
• Gene: FGFR2 / 2263
• HGNCID: 3689
• Length: 822
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 113/321 - (35%)
• Similarity: 170/321 - (52%)
• Gaps: 44/321 - (13%)

  Fly   501 SSPCDRPVPPTAGLSH------DKWEIHPMELMLMEELGSGQFGVV--------RRGKWRGSIDT 551
            ||..|.|:  .||:|.      .|||....:|.|.:.||.|.||.|        .:.|.:.::..
Human   453 SSTADTPM--LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTV 515

  Fly   552 AVKMMKEGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRH 613
            ||||:|:....:|  |.:.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..|||..
Human   516 AVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 580

  Fly   614 EKTLIGNMGL------------------LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENV 660
            ...     |:                  |:....|:::||.||.....|||||||||.||...||
Human   581 RPP-----GMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640

  Fly   661 VKVADFGLARYVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            :|:|||||||.:.: |.|..:...:.|:||..||.|....::.:||||::|||||||||.|..||
Human   641 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 705

  Fly   725 GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLT 785
            ..:...|:.:.::.|..::||.:|..|:|.:|:.||...|.:||.|:.|::.|..:. |||
Human   706 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-TLT 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	2/3 (67%)
		PTKc_Tec_like	521..778	CDD:173637	99/286 (35%)
FGFR2	NP_075259.4	IgI_1_FGFR	31..124	CDD:409362
		Ig strand A	31..34	CDD:409362
		Ig strand A'	47..53	CDD:409362
		Ig strand B	56..66	CDD:409362
		Ig strand C	69..74	CDD:409362
		Ig strand C'	77..79	CDD:409362
		Ig strand D	84..88	CDD:409362
		Ig strand E	91..96	CDD:409362
		Ig strand F	102..111	CDD:409362
		Ig strand G	114..124	CDD:409362
		IgI_2_FGFR	154..248	CDD:409443
		Ig strand A	154..157	CDD:409443
		Ig strand A'	165..170	CDD:409443
		Ig strand B	174..182	CDD:409443
		Ig strand C	188..193	CDD:409443
		Ig strand C'	196..198	CDD:409443
		Ig strand D	207..210	CDD:409443
		Ig strand E	214..219	CDD:409443
		Ig strand F	228..235	CDD:409443
		Ig strand G	238..248	CDD:409443
		Ig	256..358	CDD:472250
		Ig strand B	274..278	CDD:409353
		Ig strand C	287..291	CDD:409353
		Ig strand E	323..327	CDD:409353
		Ig strand F	337..342	CDD:409353
		Ig strand G	350..353	CDD:409353
		PTKc_FGFR2	457..769	CDD:270679	111/317 (35%)