Protein Alignment Btk29A and Yes1

DIOPT Version :9

• Sequence 1: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001192061.1
• Gene: Yes1 / 22612
• MGIID: 99147
• Length: 541
• Species: Mus musculus
• Alignment Length: 575
• Identity: 211/575 - (36%)
• Similarity: 315/575 - (54%)
• Gaps: 65/575 - (11%)

  Fly   216 GCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLG------ 274
            ||..:    :.|.:|:...:| :|.|..:||::    |.:.::|.:........|..:.
Mouse     2 GCIKS----KENKSPAIKYTP-ENLTEPVSPSA----SHYGVEHATVAPTSSTKGASVNFNSLSM 57

  Fly   275 --GGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
              .|||.|:...||...|.:..|....:.||                     ||
Mouse    58 TPFGGSSGVTPFGGASSSFSVVSSSYPTGLT---------------------GG----------- 90

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKA 401
                  |.:.||||.::|....|||.:|...:::|::::..||:.:. |.|..||||||||.|..
Mouse    91 ------VTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPAD 149

  Fly   402 LLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHI 462
            .:..|  |||.|.|.|:.||. ||..|::.|.|:||:| :|||.|:||:.  .:|...:||||.|
Mouse   150 SIQAE--EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKI 212

  Fly   463 KQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELM 527
            ::.....||::.:...:|:..|:.::..::.|| |...::.|....|.|.||:.|.|||....|.
Mouse   213 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGL-CHKLTTVCPTVKPQTQGLAKDAWEIPRESLR 276

  Fly   528 LMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHR 592
            |..:||.|.||.|..|.|.|:...|:|.:|.|||..:.|::||::|.||:|..||.||.|.|: .
Mouse   277 LEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-E 340

  Fly   593 PIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGS 657
            |||||||:|..||||::|:..:...: .:..|:||..|::.||.|:||.|||||||.|.|.|||.
Mouse   341 PIYIVTEFMSKGSLLDFLKEGDGKYL-KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE 404

  Fly   658 ENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKM 722
            ..:.|:|||||||.:.|::||:..|.||||||..||...|.||:.|||||::|:|..|:.|.|::
Mouse   405 NLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRV 469

  Fly   723 PYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ||..:.|.||:|:|:||..:..|:.|.:.::::|.|||...|:|||.|..:...|
Mouse   470 PYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	2/5 (40%)
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	119/257 (46%)
		Pkinase_Tyr	526..777	CDD:285015	117/250 (47%)
Yes1	NP_001192061.1	SH3_Yes	92..149	CDD:212940	23/56 (41%)
		SH2_Src_family	152..251	CDD:199827	36/101 (36%)
		PTKc_Yes	262..540	CDD:270654	124/265 (47%)
		Pkinase_Tyr	275..524	CDD:285015	117/250 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820