Protein Alignment Btk and FGFR3

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 141/522 - (27%)
• Similarity: 225/522 - (43%)
• Gaps: 114/522 - (21%)

  Fly   355 AIEGGDLSLEKNAEYEVIDDSQEH--WWKVKDALGN-VGYIPSNYV------------------- 397
            |:.|.|:..    ..:|..|:|.|  |.|..:..|: ||...:.||
Human   265 AVLGSDVEF----HCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRL 325

  Fly   398 -------------KPKALLGLERYEWYVGDMSRQRAESLLKQGDKEG--------------CFV- 434
                         :....:|:....:::.....:.||..|.:.|:.|              .|:
Human   326 ANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFIL 390

  Fly   435 ---------VRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRH 490
                     :|....|||.:.::|      .:..:.:|:.....  |.......:...|:...|.
Human   391 VVAAVTLCRLRSPPKKGLGSPTVH------KISRFPLKRQVTVS--LESNASMSSNTPLVRIARL 447

  Fly   491 NSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG-------- 547
            :||........|..:.|..|       |||:....|.|.:.||.|.||.|...:..|
Human   448 SSGEGPTLANVSELELPADP-------KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK 505

  Fly   548 SIDTAVKMMKEGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNY 609
            .:..||||:|:....:|  |.:.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..:
Human   506 PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF 570

  Fly   610 LRRHEKTLIGNMGL------------------LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            ||.....     ||                  |:....||::||.||.....|||||||||.||.
Human   571 LRARRPP-----GLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT 630

  Fly   657 SENVVKVADFGLARYVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            .:||:|:|||||||.|.: |.|..:...:.|:||..||.|....::.:||||::|||:|||||.|
Human   631 EDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLG 695

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL-ALVAQTL 784
            ..||..:...|:.:.::.|..::||.:|..::|.:|:.||...|.:||.|:.|::.| .::..|.
Human   696 GSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS 760

  Fly   785 TD 786
            ||
Human   761 TD 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	14/78 (18%)
		SH2_Tec_family	403..505	CDD:198188	19/125 (15%)
		PTKc_Tec_like	521..778	CDD:173637	100/287 (35%)
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443
		Ig strand A	151..154	CDD:409443
		Ig strand A'	162..167	CDD:409443
		Ig strand B	171..179	CDD:409443
		Ig strand C	185..190	CDD:409443
		Ig strand C'	193..195	CDD:409443
		Ig strand D	204..207	CDD:409443
		Ig strand E	211..216	CDD:409443
		Ig strand F	225..232	CDD:409443
		Ig strand G	235..245	CDD:409443
		IgI_3_FGFR	253..354	CDD:409363	15/92 (16%)
		Ig strand A	253..256	CDD:409363
		Ig strand A'	260..264	CDD:409363
		Ig strand B	272..279	CDD:409363	1/10 (10%)
		Ig strand C	283..290	CDD:409363	2/6 (33%)
		Ig strand D	305..310	CDD:409363	2/4 (50%)
		Ig strand E	321..326	CDD:409363	0/4 (0%)
		Ig strand F	334..342	CDD:409363	0/7 (0%)
		Ig strand G	345..353	CDD:409363	1/7 (14%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	108/312 (35%)