Protein Alignment Btk and Txk

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_036020891.1
• Gene: Txk / 22165
• MGIID: 102960
• Length: 543
• Species: Mus musculus
• Alignment Length: 461
• Identity: 227/461 - (49%)
• Similarity: 302/461 - (65%)
• Gaps: 24/461 - (5%)

  Fly   325 GGI------PTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK 383
            ||:      |.|..|.....:...    |.|||.|...|.|:|:|::..||.:::....||||.:
Mouse    92 GGVQPSKRKPLPPLPQEPPDERIQ----VKALYDFLPREPGNLALKRAEEYLILERCDPHWWKAR 152

  Fly   384 DALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSL 448
            |..||.|.||||||....|..||.||||..:::|.:.|.||:|..|||.|:||.|...|.||:|:
Mouse   153 DRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISV 217

  Fly   449 HTKV---PQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK-----SSPCD 505
            .|:.   .||.:|||.||:|...::|::|:|...::|:||.||::|:.||..||:     ...|
Mouse   218 FTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSC- 281

  Fly   506 RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEA 570
              :|.|:|.|::||||.|.||..::|:||||||||..|:||..|..|:|.:.||:|||:||||||
Mouse   282 --LPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEA 344

  Fly   571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGM 635
            |||.||.|..||||||||.:.:|:|||||:|::|.||:|||..:..|  ...|||.||..:.:||
Mouse   345 KVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQL--QKALLLSMCQDICEGM 407

  Fly   636 TYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRF 700
            .||||..|||||||||||||.|..|||::|||:|||||||:|.||.|.|||:||.||||.::.::
Mouse   408 AYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKY 472

  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE 765
            |||||||::||||||:||.||||:....|.:|||.:.:|..|.:|......||.||..|| |...
Mouse   473 SSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCW-HETL 536

  Fly   766 ERPAFR 771
            ::|.|:
Mouse   537 QKPVFQ 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	25/52 (48%)
		SH2_Tec_family	403..505	CDD:198188	44/109 (40%)
		PTKc_Tec_like	521..778	CDD:173637	144/251 (57%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840	25/57 (44%)
		SH2_Tec_Txk	172..277	CDD:198261	44/104 (42%)
		Protein Kinases, catalytic domain	295..543	CDD:473864	144/251 (57%)