DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and PTK2B

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_004094.3 Gene:PTK2B / 2185 HGNCID:9612 Length:1009 Species:Homo sapiens


Alignment Length:374 Identity:121/374 - (32%)
Similarity:190/374 - (50%) Gaps:53/374 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   426 QGDKEGCFVV--RKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET-----IPD 483
            ||:.:|..::  ||...|       ...:||..:.:...:::     :|||....|:     |||
Human   355 QGEHQGSLIIHPRKDGEK-------RNSLPQIPMLNLEARRS-----HLSESCSIESDIYAEIPD 407

  Fly   484 LINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG- 547
                              ....||..|..|::.:       :::|...||.|.||.|..|.:.. 
Human   408 ------------------ETLRRPGGPQYGIARE-------DVVLNRILGEGFFGEVYEGVYTNH 447

  Fly   548 ---SIDTAVKMMKEGTM--SEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607
               .|:.|||..|:...  :::.|:.||.:|..|.||::|:|.|:. :..|.:|:.|...:|.|.
Human   448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELG 511

  Fly   608 NYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV 672
            :||.|::.:|  .:..|:...:|:.|.|.|||..|.:|||:|.||.||.|...||:.||||:||:
Human   512 HYLERNKNSL--KVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574

  Fly   673 LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ 737
            .|:.|..:..|:.||||..||.:|:.||::.||||.:.|.||||.:.||.|:..|:|.:|:..::
Human   575 EDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLE 639

  Fly   738 RGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            :|..|.||..|...:|.:|..||.:.|.:||.|..|:..|:.|.|...|
Human   640 KGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKD 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 15/85 (18%)
PTKc_Tec_like 521..778 CDD:173637 98/262 (37%)
PTK2BNP_004094.3 FERM_N_2 39..137 CDD:436229
B41 41..254 CDD:214604
FERM_C_FAK1 261..368 CDD:270011 3/12 (25%)
PTKc_FAK 418..687 CDD:133187 102/278 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725
Interaction with TGFB1I1. /evidence=ECO:0000250 801..1009
Focal adhesion targeting (FAT) 868..1009
Focal_AT 872..1001 CDD:460992
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.