DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and Tec

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001106931.1	Gene:	Tec / 21682	MGIID:	98662	Length:	630	Species:	Mus musculus

Alignment Length:	754	Identity:	304/754 - (40%)
Similarity:	418/754 - (55%)	Gaps:	139/754 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEAT 104
            ::.:....::||:|.||:.:|:|||.|.|.|||...||:: ...|::..:|.|.:..::.||  .
Mouse     3 FNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLSYYE-GRAEKKYRKGVIDISKIKCVE--I 64

  Fly   105 VSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSE 169
            |..:.|.....:.:||||.:     .||                            |||:.|.|.
Mouse    65 VKNDDGVIPCQNKFPFQVVH-----DAN----------------------------TLYIFAPSP 96

  Fly   170 KERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGS 234
            :.|..|::.:::..:::|. ...:|||..|:...:.||:...:...||
Mouse    97 QSRDRWVKKLKEEIKNNNN-IMIKYHPKFWADGSYQCCRQTEKLAPGC----------------- 143

  Fly   235 SPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQ 299
                              .:::|..:|                              ...:|.|.
Mouse   144 ------------------EKYNLFESS------------------------------IRKTLPPA 160

  Fly   300 SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE 364
            ..:.  |:.|                  |.|..|.   ::|:.  ::|||:|.|:|.|..||.||
Mouse   161 PEIK--KRRP------------------PPPIPPE---EENTE--EIVVAMYDFQATEAHDLRLE 200

  Fly   365 KNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429
            :..||.:::.:..|||:.:|..|:.||||||||..|....|::||||..:.:|.:||.||:..||
Mouse   201 RGQEYIILEKNDLHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDK 265

  Fly   430 EGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQNARC--EYYLSEKHCCETIPDLINYHR 489
            ||.|:||.||..||||:||:||.   ..|..:|||||:.|..  :|||:|||...:||::|.||:
Mouse   266 EGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHK 330

  Fly   490 HNSGGLACRLK--SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTA 552
            ||:.||..||:  .|...:..|.|||.|:|||||:|.||..|.|||||.|||||.||||.....|
Mouse   331 HNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVA 395

  Fly   553 VKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTL 617
            :|.::||.|.|:|||||||||.||.||.||||||||::.:|||||||:|:.|.|||:||:.:...
Mouse   396 IKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF 460

  Fly   618 IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGG 682
            ..:|  ||.||..|.:||.||||:::||||||||||||....||||:|||:||||||||||||.|
Mouse   461 SRDM--LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSG 523

  Fly   683 TKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKS 747
            .|||:||.||||.||:|||||||||::|||||||||.|:||:.:..|.|||..|.||..|.:||.
Mouse   524 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRPKL 588

  Fly   748 CAKEIYDVMKLCWSHGPEERPAFRVLM---DQLALVAQT 783
            .:|.:|:||..||...||.||:|..|:   |:|....:|
Mouse   589 ASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEET 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	45/177 (25%)
		SH3_Tec_like	346..399	CDD:212702	26/52 (50%)
		SH2_Tec_family	403..505	CDD:198188	52/108 (48%)
		PTKc_Tec_like	521..778	CDD:173637	159/259 (61%)
		Pkinase_Tyr	526..777	CDD:285015	156/253 (62%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944	45/212 (21%)
		SH3_Tec	182..236	CDD:212838	26/53 (49%)
		SH2_Tec_Itk	239..346	CDD:198259	51/106 (48%)
		PTKc_Tec_Rlk	364..623	CDD:270685	160/260 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1270
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1302
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1093
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm44145
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4487
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860