DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and Syk

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_035648.2 Gene:Syk / 20963 MGIID:99515 Length:629 Species:Mus musculus


Alignment Length:586 Identity:159/586 - (27%)
Similarity:253/586 - (43%) Gaps:150/586 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 GGGGSCTPTSL------QPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDN--SH 342
            ||....:|..|      :|...:...|:            ..|.|.|:.....|....|:|  ..
Mouse    77 GGRAHASPADLCHYHSQEPDGLICLLKK------------PFNRPPGVQPKTGPFEDLKENLIRE 129

  Fly   343 FVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLER 407
            :||....|.. :|:|...:|.:...|                             |..|....|:
Mouse   130 YVKQTWNLQG-QALEQAIISQKPQLE-----------------------------KLIATTAHEK 164

  Fly   408 YEWYVGDMSRQRAESLLKQGDK-EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYY 471
            ..|:.|::||..:|..:..|.| .|.|::|.....|.|.|.|   :.:..|.||.|.::...:..
Mouse   165 MPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCL---LHEGKVLHYRIDRDKTGKLS 226

  Fly   472 LSEKHCCETIPDLINYHRH---------------------------------NSGGLACRLKS-- 501
            :.|....:|:..|:.::.:                                 :.||:..|:||  
Mouse   227 IPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYS 291

  Fly   502 --------------------------SPCDRPVPPTAGLSH---------------DKWEIHPME 525
                                      .|...|..|..||..               |..||.|.|
Mouse   292 FPKPGHKKPAPPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKE 356

  Fly   526 ------LMLME--ELGSGQFGVVRRG--KWRGSIDT-AVKMMKEGTMS---EDDFIEEAKVMTKL 576
                  |:.:|  |||||.||.|::|  :.:..:.| |||::|.....   :|:.:.||.||.:|
Mouse   357 VYLDRSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 421

  Fly   577 QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERH 641
            .:|.:|::.|:|.....: :|.|..:.|.|..||:::......|   ::::..|||.||.|||..
Mouse   422 DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHIKDKN---IIELVHQVSMGMKYLEES 482

  Fly   642 NYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKS 704
            |::||||||||.|:.:::..|::||||::.:..|:  |.:....|:|:||..||.:||.:|||||
Mouse   483 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 547

  Fly   705 DVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPA 769
            |||::||||||.|:.|:.||..:|.:||...:::|..:..|..|.:|:||:|.|||::..|.||.
Mouse   548 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPG 612

  Fly   770 F 770
            |
Mouse   613 F 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 5/52 (10%)
SH2_Tec_family 403..505 CDD:198188 28/163 (17%)
PTKc_Tec_like 521..778 CDD:173637 104/266 (39%)
SykNP_035648.2 SH2_N-SH2_Zap70_Syk_like 12..115 CDD:198191 9/49 (18%)
Interdomain A 107..166 16/88 (18%)
SH2_C-SH2_Syk_like 163..261 CDD:198264 22/100 (22%)
Interdomain B 259..364 15/104 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..328 3/34 (9%)
PTKc_Syk 370..625 CDD:133247 99/248 (40%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.