DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Srms

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_035611.3	Gene:	Srms / 20811	MGIID:	101865	Length:	507	Species:	Mus musculus

Alignment Length:	465	Identity:	167/465 - (35%)
Similarity:	244/465 - (52%)	Gaps:	26/465 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 PGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-DALG 387
            |...|.|.            .:|..|||.|.|....:||:.:......:.:..::.:..: ....
Mouse    60 PCSFPAPR------------ARLFRALYDFTARCAEELSVSRGDRLYALKEEGDYIFAQRLSGPP 112

  Fly   388 NVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKS-STKGLYTLSLHT 450
            :.|.:|..|:............||...:||.:|:. ||...:..|.|::|.| |:.|.|:||:..
Mouse   113 STGLVPVTYLAKATPEPPSDQPWYFSGISRAQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRA 177

  Fly   451 KVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS 515
               |:.|.||.|........||.|.....::..|:.|::.|     .:|..:|..:|..|...|.
Mouse   178 ---QAKVCHYRICMAPSGSLYLQEGQLFPSLDALLAYYKTN-----WKLIQNPLLQPCIPQIPLV 234

  Fly   516 HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPN 580
            .|:||....|.:|..:||.|.||.|..|.|.|||..|||::|...|...|..:|.:.:..|:|..
Mouse   235 QDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHER 299

  Fly   581 LVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE-KTLIGNMGLLLDMCIQVSKGMTYLERHNYI 644
            |::|:.:||...|:|||||.|..|:|..||...| |.|  ::..||....||::||:|||....:
Mouse   300 LIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKAL--SLPHLLGFACQVAEGMSYLEERRVV 362

  Fly   645 HRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAY 709
            ||||||||.|||.:...|||||||||.:.||.|:.|.|:|.|:||..||..||..||.|||||::
Mouse   363 HRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSF 427

  Fly   710 GVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
            |:|::|:||.|:.||..:.|.|.::::.||..|.:|..|..|:|.:|..||...|||||.|.:|.
Mouse   428 GILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILR 492

  Fly   775 DQLALVAQTL 784
            ::|..:.:.|
Mouse   493 EKLNAINRRL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	11/53 (21%)
		SH2_Tec_family	403..505	CDD:198188	29/103 (28%)
		PTKc_Tec_like	521..778	CDD:173637	116/257 (45%)
		Pkinase_Tyr	526..777	CDD:285015	115/251 (46%)
Srms	NP_035611.3	SH3	70..124	CDD:302595	11/53 (21%)
		SH2_Srm	134..212	CDD:198223	25/80 (31%)
		PTKc_Srm_Brk	238..498	CDD:133248	119/261 (46%)
		STYKc	246..495	CDD:214568	115/250 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820