Protein Alignment Btk and Src

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006499126.1
• Gene: Src / 20779
• MGIID: 98397
• Length: 552
• Species: Mus musculus
• Alignment Length: 587
• Identity: 209/587 - (35%)
• Similarity: 296/587 - (50%)
• Gaps: 102/587 - (17%)

  Fly   231 SNGSSP--AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTP 293
            ||.|.|  |....||:.|:.:.        |                      |.||....|.||
Mouse     3 SNKSKPKDASQRRRSLEPSENV--------H----------------------GAGGAFPASQTP 37

  Fly   294 TS-------LQPQSSLTTFKQSPTLLNGNGTLLDANMP-------GGIPTPGTPNSKAKDNSHFV 344
            :.       ..|.::.......|.|..|..:......|       ||:.|
Mouse    38 SKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT--------------- 87

  Fly   345 KLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQE-----------------HWWKVKD-ALGNVGY 391
              .||||.:::....|||.:|....::::::::                 .||.... :.|..||
Mouse    88 --FVALYDYESRTETDLSFKKGERLQIVNNTRKVDVSQTWFTFRWLQREGDWWLAHSLSTGQTGY 150

  Fly   392 IPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK-EGCFVVRKS-STKGLYTLSL--HTKV 452
            ||||||.|...:..|  |||.|.::|:.:|.||...:. .|.|:||:| :|||.|.||:  ....
Mouse   151 IPSNYVAPSDSIQAE--EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNA 213

  Fly   453 PQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHD 517
            ...:||||.|::.....:|::.:....::..|:.|:..::.||..|| ::.|....|.|.||:.|
Mouse   214 KGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL-TTVCPTSKPQTQGLAKD 277

  Fly   518 KWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLV 582
            .|||....|.|..:||.|.||.|..|.|.|:...|:|.:|.||||.:.|::||:||.||:|..||
Mouse   278 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 342

  Fly   583 QLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG------LLLDMCIQVSKGMTYLERH 641
            |||.|.|: .|||||||||..||||::|:       |..|      .|:||..|::.||.|:||.
Mouse   343 QLYAVVSE-EPIYIVTEYMNKGSLLDFLK-------GETGKYLRLPQLVDMSAQIASGMAYVERM 399

  Fly   642 NYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDV 706
            ||:||||.|.|.|||...|.|||||||||.:.|::||:..|.||||||..||...|.||:.||||
Mouse   400 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 464

  Fly   707 WAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFR 771
            |::|:|:.|:.|.|::||..:.|.||:::|:||..:..|..|.:.::|:|..||...|||||.|.
Mouse   465 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 529

  Fly   772 VL 773
            .|
Mouse   530 YL 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/70 (27%)
		SH2_Tec_family	403..505	CDD:198188	32/105 (30%)
		PTKc_Tec_like	521..778	CDD:173637	126/259 (49%)
Src	XP_006499126.1	SH3_Src	87..159	CDD:212941	20/88 (23%)
		SH2_Src_Src	163..263	CDD:198228	32/102 (31%)
		PTKc_Src	276..552	CDD:270656	129/264 (49%)