DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Ptk6

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_033210.1	Gene:	Ptk6 / 20459	MGIID:	99683	Length:	451	Species:	Mus musculus

Alignment Length:	451	Identity:	166/451 - (36%)
Similarity:	238/451 - (52%)	Gaps:	26/451 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 DNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW-KVKDALGNV---GYIPSNYVKP 399
            |.:|.....|.|:.|||....:||.:......|....:..|| .:.||.|..   ||:|.||:..
Mouse     5 DKAHLGPKYVGLWDFKARTDEELSFQAGDLLHVTKKEELWWWATLLDAEGKALAEGYVPHNYLAE 69

  Fly   400 KALLGLERYEWYVGDMSRQRAESLLKQGD-KEGCFVVRKSSTKGL-YTLSLHTKVPQSHVKHYHI 462
            |..  :|...|:.|.:||..|...|:..| .:|.|::|.|...|. |.||:.   ....|:||.|
Mouse    70 KET--VESEPWFFGCISRSEAMHRLQAEDNSKGAFLIRVSQKPGADYVLSVR---DAQAVRHYRI 129

  Fly   463 KQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC----DRPVPPTAGLSH-DKWEIH 522
            .:|.....:|:|......:.:|::||:..|.....:| |.||    ..|:|      | |.||..
Mouse   130 WKNNEGRLHLNEAVSFSNLSELVDYHKTQSLSHGLQL-SMPCWKHKTEPLP------HWDDWERP 187

  Fly   523 PMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMM-KEGTMSEDDFIEEAKVMTKLQHPNLVQLYG 586
            ..|..|.::||:|.||.|....|:|.:..|||:: ::..:.:..|..|.:.|.||:|.:::.||.
Mouse   188 REEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYA 252

  Fly   587 VCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAAR 651
            |.:...|:||:||.|..|:||..||..::..:..:. |:|...||::||.|||..||||||||||
Mouse   253 VATAGDPVYIITELMPKGNLLQLLRDSDEKALPILE-LVDFASQVAEGMCYLESQNYIHRDLAAR 316

  Fly   652 NCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEI 716
            |.||...|:.||.||||||.|.:|.|.|. ....|.||..||.|:...:|.|||||::|||:.||
Mouse   317 NVLVTENNLCKVGDFGLARLVKEDIYLSH-EHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEI 380

  Fly   717 FTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |:.|:|||..:.|.|...||..|..:..|..|...|:.:|..|||..|::||.|:.|.::|
Mouse   381 FSRGQMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/56 (32%)
		SH2_Tec_family	403..505	CDD:198188	31/107 (29%)
		PTKc_Tec_like	521..778	CDD:173637	108/258 (42%)
		Pkinase_Tyr	526..777	CDD:285015	106/251 (42%)
Ptk6	NP_033210.1	SH3	12..69	CDD:302595	18/56 (32%)
		SH2_PTK6_Brk	75..174	CDD:198221	30/102 (29%)
		Linker	171..190		6/24 (25%)
		PKc_like	184..444	CDD:304357	110/260 (42%)
		STYKc	192..441	CDD:214568	106/250 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820