Protein Alignment Btk and Ros1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_011241449.1
• Gene: Ros1 / 19886
• MGIID: 97999
• Length: 2341
• Species: Mus musculus
• Alignment Length: 923
• Identity: 237/923 - (25%)
• Similarity: 365/923 - (39%)
• Gaps: 248/923 - (26%)

  Fly     1 MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAK--------MDLMSERLY-----DVVKSGSMVKRA 52
            :|.||. ::.:..:.|.|.::.|..|:.::|        :....::.|     |:|:  :.:..|
Mouse  1393 IMKTKD-DAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVE--ATILYA 1454

  Fly    53 QNKK---RFTPVNYKHRWFELTKRTFSY--FDVENVERRRERGRIHLKGVRLVE--EATVSGEGG 110
            .|..   :..||.....|..:|..|.:|  :.:| ..|.....|.|    :::|  |.....||.
Mouse  1455 TNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYME-ANRANSSDRRH----KMLESQENVARIEGL 1514

  Fly   111 DPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQ-QSGRAVPQYTLYVIA-------- 166
            .||:.  |..|:......:....|.       ..|..|:|| :||  ||....::.|
Mouse  1515 QPFSM--YMIQIAVKNYYSEPLEHL-------PLGKEIQGQTKSG--VPGAVCHINATVLSDTSL 1568

  Fly   167 ----------NSEKERSEWIRAIRQVCEDSNTPKSYRYHPGL--------WSGKKWSCCKGLSRT 213
                      |..||...:...:..:.....||......|..        .||.:....|.|:
Mouse  1569 HVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQLYVMKVLA-- 1631

  Fly   214 TFGCRAAAHWREANNN----------------PSNGSSPAQNSTRSISPNSSTTNSQFSLQ---- 258
               |.....|...::.                |.|.|.......||   |.:.|...|.||
Mouse  1632 ---CHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARS---NVNLTGFWFELQKWKY 1690

  Fly   259 ----HNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS--------LTTFKQSPTL 311
                |..:....|.|                   ..|..|.|||.:|        .||.:.|.::
Mouse  1691 NEFYHVKASCSQGPV-------------------YVCNITDLQPYTSYNIRVVVVYTTGENSSSI 1736

  Fly   312 LNGNGTLLDANMPGGIP--TPGTPNS----KAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYE 370
            .....|........|||  ..|:.||    ||:||..  :|:  .|..:..:|
Mouse  1737 PESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGS--RLM--YYTLEVRKG------------ 1785

  Fly   371 VIDDSQ---EHW-------------WKVKDALGNVGY--IPSNYVKPKALLGLERYEWYVGDMSR 417
            :.:|||   ..|             |:.|:..|...:  :.:|.:      ||..|.....|:
Mouse  1786 ISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEI------GLGEYSEISEDI-- 1842

  Fly   418 QRAESLLKQG--DKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLS-----EK 475
                :|::.|  ..|..|::  :...|::   |...||.:.|.|..:|.:...:..||     :|
Mouse  1843 ----TLVEDGVWITETSFIL--TIIVGIF---LVATVPLTFVWHRSLKSHKASKEGLSVLNDNDK 1898

  Fly   476 HCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIH--------------PME- 525
            ...|.            .|||..:             ||::..:.:|              |.|
Mouse  1899 ELAEL------------RGLAAGV-------------GLANACYAVHTVPTQEEIENLPAFPREK 1938

  Fly   526 LMLMEELGSGQFGVVRRGK-------WRGSIDTAVKMMKEGTMSED--DFIEEAKVMTKLQHPNL 581
            |.|...||||.||.|..|.       ..|.|..|||.:|:|:..::  :|::||.:|:|..|||:
Mouse  1939 LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 2003

  Fly   582 VQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGL----LLDMCIQVSKGMTYLERHN 642
            ::..|||....|.||:.|.|:.|.||:|||:...|......|    |:::|:.:|||..|||:.:
Mouse  2004 LKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMH 2068

  Fly   643 YIHRDLAARNCLVG-----SENVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPPEVLNYTRFS 701
            :||||||||||||.     |..|||:.||||||.:. :|.|...|....|::|..||.|....|:
Mouse  2069 FIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFT 2133

  Fly   702 SKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEE 766
            |:||||::|:|:|||.|.|..||....|.:|:..||.|..||.|::|..:::::|..||:..|::
Mouse  2134 SQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQ 2198

  Fly   767 RPAFRVLMDQLAL 779
            ||.|..:.:||.|
Mouse  2199 RPTFHNIQNQLQL 2211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	41/211 (19%)
		SH3_Tec_like	346..399	CDD:212702	11/70 (16%)
		SH2_Tec_family	403..505	CDD:198188	22/108 (20%)
		PTKc_Tec_like	521..778	CDD:173637	114/290 (39%)
Ros1	XP_011241449.1	FN3	<100..>296	CDD:442628
		FN3	568..664	CDD:238020
		FN3	1037..1143	CDD:238020
		FN3	<1502..>1753	CDD:442628	54/288 (19%)
		FN3	1651..1742	CDD:238020	22/112 (20%)
		FN3	1747..1840	CDD:238020	24/114 (21%)
		PTKc_c-ros	1949..2210	CDD:270640	105/260 (40%)