DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Ptk2b

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_017171415.1 Gene:Ptk2b / 19229 MGIID:104908 Length:1020 Species:Mus musculus


Alignment Length:415 Identity:132/415 - (31%)
Similarity:204/415 - (49%) Gaps:62/415 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 LGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE---SLLKQGDKEGCFVVRKSSTKGLYTLS 447
            ||..|...|..:|..:|...|.....:....|.:.|   ||:....|:|   .:::|...:.||:
Mouse   322 LGIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGSLIMHAKKDG---EKRNSLPQIPTLN 383

  Fly   448 LHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET-----IPDLINYHRHNSGGLACRLKSSPCDRP 507
            |..:  :||               |||....|:     |||                  ....||
Mouse   384 LEAR--RSH---------------LSESCSIESDIYAEIPD------------------ETLRRP 413

  Fly   508 VPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG----SIDTAVKMMKEGTM--SEDDF 566
            ..|..|::.:       |::|...||.|.||.|..|.:..    .|:.|||..|:...  :::.|
Mouse   414 GGPQYGVARE-------EVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKF 471

  Fly   567 IEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQV 631
            :.||.:|..|.||::|:|.|:. :..|.:|:.|...:|.|.:||.|::.:|  .:..|:...:|:
Mouse   472 MSEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSL--KVPTLVLYTLQI 533

  Fly   632 SKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLN 696
            .|.|.|||..|.:|||:|.||.||.|...||:.||||:||:.|:.|..:..|:.||||..||.:|
Mouse   534 CKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598

  Fly   697 YTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWS 761
            :.||::.||||.:.|.||||.:.||.|:..|:|.:|:..:::|..|.||:.|...:|.:|..||.
Mouse   599 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWD 663

  Fly   762 HGPEERPAFRVLMDQLALVAQTLTD 786
            :.|.:||.|..|:..|:.:.|...|
Mouse   664 YDPSDRPRFTELVCSLSDIYQMEKD 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 4/12 (33%)
SH2_Tec_family 403..505 CDD:198188 20/109 (18%)
PTKc_Tec_like 521..778 CDD:173637 99/262 (38%)
Ptk2bXP_017171415.1 FERM_N_2 39..137 CDD:436229
B41 41..254 CDD:214604
FERM_C_FAK1 261..368 CDD:270011 11/45 (24%)
PTKc_FAK 418..687 CDD:133187 102/278 (37%)
Focal_AT 883..1012 CDD:460992
Blue background indicates that the domain is not in the aligned region.

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