Protein Alignment Btk and Y52D5A.2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_500813.3
• Gene: Y52D5A.2 / 190185
• WormBaseID: WBGene00021793
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 485
• Identity: 127/485 - (26%)
• Similarity: 207/485 - (42%)
• Gaps: 107/485 - (22%)

  Fly   327 IPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKN---AEYEVIDDSQEHWWKVKDALGN 388
            :|:...||.|...:....||          :.|:.::..:   :...:.||.:|.
 Worm    23 VPSDIEPNDKRPIDPRADKL----------DMGNKNVSSSMTLSNTSMHDDPEEE---------- 67

  Fly   389 VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST---KGLYTLSLHT 450
              ||.::      |:.|..|.   |.:.....|.:| |.|:.  ::||::.|   |....:|::.
 Worm    68 --YIRNH------LINLHVYH---GVLFGSEVEKIL-QWDRS--YLVRRAITEPMKKFLCISVNW 118

  Fly   451 KVPQSHVKHYHIKQNARCEYYLSEKHCC----ETIPDLINYH-RHNSGGLACRLKSSPCDRPVP- 509
            |   :.|.||.:..|       .:...|    |..|.:.... .|.|..|....:::|...|:|
 Worm   119 K---NKVFHYQLDFN-------DDGWSCTKLYEKFPPMPKRRFLHMSQLLEVWSQATPFLIPMPR 173

  Fly   510 -PTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR--GS----IDTAVKMM--KEGTMSEDD 565
             |.. |.|.       .::|.::||||.||||.:||::  ||    ::.|||.:  ........:
 Worm   174 RPNV-LFHS-------TVLLEKKLGSGAFGVVFKGKYQAFGSTNPPLEVAVKRIIGNSNRKQIQE 230

  Fly   566 FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR------RHEKTLIGNMGLL 624
            |..||::|:.|||.|:|...|..|...||.:|.|       |.|||      :.:         :
 Worm   231 FCNEAQIMSMLQHDNMVAFRGFASLEEPIMVVME-------LKYLRTTRDIPKRQ---------I 279

  Fly   625 LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKW 689
            ....:.|:.||.:|.....||||||||||||..:...|::||||:  ....:.|.:...:.|::|
 Worm   280 FWFAMNVASGMKHLSSKGIIHRDLAARNCLVTQDLKAKISDFGLS--CQGTEVTVTNLCRAPLRW 342

  Fly   690 APPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPY--GRLKNTE---VVERVQRGIILEKPKSC 748
            ..||..|...|:.|:|||:||||:.|:.| |...|.  ..||:.:   ..|.....|:...|
 Worm   343 MAPESFNSGTFNEKTDVWSYGVLLTELMTRCEHDPLYPMSLKDAKAWIASESFPHRIVNGDP--- 404

  Fly   749 AKEIYDVMKLCWSHGPEERPAFRVLMDQLA 778
             ||:..::..|.....::|..|..:..:::
 Worm   405 -KELMSLVDACCDKNVKDRIKFNTVKRRIS 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	7/55 (13%)
		SH2_Tec_family	403..505	CDD:198188	24/109 (22%)
		PTKc_Tec_like	521..778	CDD:173637	85/276 (31%)
Y52D5A.2	NP_500813.3	SH2	79..163	CDD:214585	22/99 (22%)
		TyrKc	183..432	CDD:197581	85/270 (31%)