Protein Alignment Btk and W01B6.5

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_501826.2
• Gene: W01B6.5 / 189082
• WormBaseID: WBGene00012172
• Length: 536
• Species: Caenorhabditis elegans
• Alignment Length: 464
• Identity: 123/464 - (26%)
• Similarity: 213/464 - (45%)
• Gaps: 102/464 - (21%)

  Fly   327 IPTPGTPN----SKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD--- 384
            |.|...||    .|.|.|...||::           |:||.||.|:.|          |.|:
 Worm   131 IRTSVQPNKHEVEKMKKNQADVKVL-----------GNLSREKCAKKE----------KEKEEKL 174

  Fly   385 -ALGNVG---YIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYT 445
             .:|:||   ::.|.|.|                             |||     :.::.|..||
 Worm   175 AGMGDVGRREFVISVYCK-----------------------------DKE-----KPATDKPQYT 205

  Fly   446 LSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPP 510
                      .:::..||:: ....::......:|:.:...|::.|||  .|:........|:|
 Worm   206 ----------PIRNLVIKRD-NGMVHVEPLRKFKTLTEFFGYYQKNSG--ICKETDFQLITPIP- 256

  Fly   511 TAGLSHDKWE-IHPMELMLMEELGSGQFGVVRRGKW-----RGSIDTAVKMMK--EGTMSED--D 565
               ||:  || ||....:..::||.|.||.||.||.     :.:::.||||::  |..:.|.  :
 Worm   257 ---LSN--WEFIHEDIALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGE 316

  Fly   566 FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQ 630
            .:.||:||..:.|.|:::.||:.....|:|::||....|:|..|||.:::|:  .:...|...:.
 Worm   317 LLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLRENQETV--TLAEKLFFVVG 379

  Fly   631 VSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVL 695
            .|:|:.||.....||||||.||.|:..:...|::|||||:  :.::|......|.|:::..||.|
 Worm   380 SSRGVQYLHSQKTIHRDLAVRNILLSEDRTPKISDFGLAK--ISERYEMKEQCKIPVRYLAPETL 442

  Fly   696 NYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV-QRGIILEKPKSCAKEIYDVM-KL 758
            ....|::|:||:::|.::|||:..|..|:.. ||.:.:..: ::...|:...|...|:..:: :.
 Worm   443 ESFIFTTKTDVFSFGCVIWEIYENGNQPHDG-KNAQTIRNLTKKNQFLKLTNSAPSELRKLIEER 506

  Fly   759 CWSHGPEER 767
            .::..||.|
 Worm   507 VFTSDPENR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	14/59 (24%)
		SH2_Tec_family	403..505	CDD:198188	14/101 (14%)
		PTKc_Tec_like	521..778	CDD:173637	79/258 (31%)
W01B6.5	NP_501826.2	SH2	104..241	CDD:472789	34/175 (19%)
		TyrKc	272..524	CDD:197581	77/249 (31%)