Protein Alignment Btk and R151.1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001299880.1
• Gene: R151.1 / 187907
• WormBaseID: WBGene00020106
• Length: 696
• Species: Caenorhabditis elegans
• Alignment Length: 603
• Identity: 143/603 - (23%)
• Similarity: 245/603 - (40%)
• Gaps: 142/603 - (23%)

  Fly   289 GSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGI-----PTPGTPNSKAKDNSHFVKLVV 348
            |..|.:.|..:.|||.    |:..||:..::|.:....:     |.|...:....:..|.|...:
 Worm   120 GYFTSSILPDERSLTI----PSAFNGHALVIDHSCSYHLQIRAKPYPPGDDKYIIERRHTVPDCI 180

  Fly   349 ALYPFKAIEGGDLS----LEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYE 409
            ..|  .:...||::    :..:|||.:.       ||..:..|                  ..|:
 Worm   181 DKY--CSCRPGDVAAIRDVSVDAEYRLN-------WKFDEMKG------------------REYQ 218

  Fly   410 WYVGDMSRQRAESLLKQG----DKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHY---------- 460
            :||....|.....:.|:|    .:|..|.:..:.:   |.:|..:....:|...|
 Worm   219 FYVDVYERIAMPLIKKKGSEPESEEYTFRIANADS---YEISAKSAETSAHTYQYQLPFQFTPFQ 280

  Fly   461 --------------------HIKQNARCEYYLSEKHCCETIPDLI-------------------- 485
                                ||.......:..||......||::.
 Worm   281 QYKISIFAVDDSFCHNQDVFHIFNTTNATFSSSEIPKTTPIPEISGSAITKTTMLMESSILVIFL 345

  Fly   486 ---------------------------NYHRHNSGGLACR----LKSSPCDRPVPPTAGLSHDKW 519
                                       .:|..:...|:|.    ::::...||.....|.:..:|
 Worm   346 IVVACMSPICTMIVLLCLRRRKKEIKKRHHFLHRRSLSCSRHSIIETNILYRPPNEVNGGTTGEW 410

  Fly   520 EIHPMELMLMEELGSGQFGVVRRGKWRGS----IDTAVKMMKEGTMSE--DDFIEEAKVM-TKLQ 577
            .|...::::...:|.|.||.|.:|..||.    |..|||.:|...:.|  ::|:.|.::| |..|
 Worm   411 LIRGQDIVVGAVIGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQ 475

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGL----LLDMCIQVSKGMTYL 638
            |.|:|.:||.|...:...::.||:.:|.|.:||:...|....:..:    .|....|::.||.:|
 Worm   476 HDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHL 540

  Fly   639 ERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            |....|||||||||.|||:..|:|::|||::|   ...|........|::|..||.:....:|:|
 Worm   541 ESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PGVYIKMSKGVIPLRWLSPEAIKDNTYSNK 602

  Fly   704 SDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            |||||:|||:|||.|.|..||..:.:.:::.::..|:.||:|..|:.::|.:||.||:...|:||
 Worm   603 SDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRP 667

  Fly   769 AFRVLMDQLALVAQTLTD 786
            :|..::.::..:|....|
 Worm   668 SFLAILSKIEQIANVDAD 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	9/56 (16%)
		SH2_Tec_family	403..505	CDD:198188	21/186 (11%)
		PTKc_Tec_like	521..778	CDD:173637	93/267 (35%)
R151.1	NP_001299880.1	PTKc	422..677	CDD:270623	92/257 (36%)