Protein Alignment Btk and R11E3.1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_500644.2
• Gene: R11E3.1 / 187810
• WormBaseID: WBGene00020003
• Length: 549
• Species: Caenorhabditis elegans
• Alignment Length: 497
• Identity: 134/497 - (26%)
• Similarity: 229/497 - (46%)
• Gaps: 113/497 - (22%)

  Fly   357 EGGDLSLEKNAEYEVIDDSQEHW---------------------WKVKDALGNVGYIPSNYVKPK 400
            |.|::..:|:......|::||..                     .|.:.|.....|:..:.|:.:
 Worm     5 EVGEIIKKKSIRETTTDETQERRPDLTTASEEKGSEKKDEKGSDRKDESATSKSVYVEKDVVEDE 69

  Fly   401 ALL-GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVR-------KSSTKGL---YTLSL------ 448
            .|. .|:...:|.|.:.|.....:::   .||.:::|       |..|.|:   ..||:
 Worm    70 ELYKSLQAMPFYHGFLPRDDLGVIIR---NEGDYLIRVSEITTKKEGTTGIKRDIILSVCSSERG 131

  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEK------------------HCCETIPDLI-NYH------ 488
            .|:..|::.     |.:|:.|..|.|:                  :...||..|: |||
 Worm   132 GTETEQTNT-----KSDAKSELNLGERKMRNMVIRRFDGKFGIKGNLFPTIEALLANYHVTNALE 191

  Fly   489 -RHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRG---KWRGSI 549
             :.|      |...:|.|..|          ||.....:.|.::||.|.:|.||:|   :....:
 Worm   192 TKEN------RFLKTPIDLQV----------WENRHSAVKLGDKLGEGAYGEVRKGVLHRKNKKL 240

  Fly   550 DTAVKMMKEGTMSE---DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR 611
            |.|||:||.|.:::   .:.:.||::|...:|.|:|:.:||....:|:||:.|.:..|:|..||:
 Worm   241 DVAVKLMKGGELNKMKIREMMNEARLMRNFKHKNIVRFFGVAVVEQPLYILLELVNGGALNTYLQ 305

  Fly   612 RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676
            :::.:.:.    |:.||:..::|:.||..::.||||:||||||..::.|||::||||:  |:.:|
 Worm   306 KNKVSDLE----LMRMCLGAAQGLQYLHANHCIHRDIAARNCLYSNDKVVKLSDFGLS--VVGNQ 364

  Fly   677 YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII 741
            |......|.||||..||.:....|:.|:||::|||:.:|||:.|..|:..:.||.....|..||.
 Worm   365 YKLCAAQKLPIKWLAPETITTRFFTPKTDVYSYGVMCFEIFSNGAEPWEGVTNTVTKNNVVNGIN 429

  Fly   742 LEKPKSCAKEIYDVMKLCWSHGPEER-----PAFRVLMDQLA 778
            |..|:||.::....:        .|:     |..||:||.::
 Worm   430 LVIPESCPEKFRSFV--------HEKIFVVDPKRRVVMDDVS 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	10/62 (16%)
		SH2_Tec_family	403..505	CDD:198188	28/144 (19%)
		PTKc_Tec_like	521..778	CDD:173637	91/267 (34%)
R11E3.1	NP_500644.2	SH2_Fps_family	73..191	CDD:198224	25/125 (20%)
		PTKc	218..467	CDD:270623	90/260 (35%)