DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and F23C8.7

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_490975.1 Gene:F23C8.7 / 184892 WormBaseID:WBGene00017736 Length:417 Species:Caenorhabditis elegans


Alignment Length:406 Identity:127/406 - (31%)
Similarity:204/406 - (50%) Gaps:72/406 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 WYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKG----LYTLSL--HTKVPQSHVKHYHIKQNARC 468
            ||.|.:.|:..:::|:   |.|.|:||.:..|.    .|.||.  ..::..:.||||.::.|:..
 Worm    11 WYHGLLPREDIKAMLR---KNGDFLVRSTEPKAGEPRQYVLSAMQSEELEDAGVKHYVMRLNSSN 72

  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELG 533
            :.:|..|. .|||..|:||:..:         ..|..:.......:....|||...::.|.::||
 Worm    73 QIFLEAKG-FETIASLVNYYMSS---------KEPIKKLTVLKTPILKQPWEIEHSQVELTKKLG 127

  Fly   534 SGQFGVVRRGKW---RGSIDT-AVKMMKEGTMSED---DFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            .|.||.|.:||.   .|:::. |:|..|..:::::   :.:.||::|..|.|||:|:.|||.:..
 Worm   128 EGAFGEVWKGKLTLKNGNVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQ 192

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLL----LDMCIQVSKGMTYLERHNYIHRDLAARN 652
            .|:|::.|....|:|.:||::       |..|:    ::|..|.:.|::|:.....:|||:||||
 Worm   193 EPLYVIMELADCGALDSYLQK-------NPNLVPDKKMEMIYQAACGISYMHEKKLLHRDIAARN 250

  Fly   653 CLVGSENVVKVADFGLAR----YVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLM 713
            ||.|. ..||:|||||:|    ||:|  .|.    |.||:|..||.|....:|.|:||:|:|::.
 Worm   251 CLYGG-GQVKIADFGLSREGISYVMD--LTK----KVPIRWLAPETLKAGIYSPKTDVFAFGIMA 308

  Fly   714 WEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYD-----------VMKLCWSHGPEER 767
            |||...||.||..::..:||.:|:.|..:.         :|           |.|.||:    |.
 Worm   309 WEITENGKEPYPDMRVADVVGKVRNGYRMR---------FDPVFVDFRFGDYVTKHCWA----EN 360

  Fly   768 PAFRVLMDQLALVAQT 783
            ||.||.|..:....||
 Worm   361 PADRVSMADVLRYLQT 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 28/100 (28%)
PTKc_Tec_like 521..778 CDD:173637 95/282 (34%)
F23C8.7NP_490975.1 SH2_Fps_family 4..98 CDD:198224 27/99 (27%)
TyrKc 120..374 CDD:197581 94/280 (34%)
Blue background indicates that the domain is not in the aligned region.

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