Protein Alignment Btk and trk-1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001360632.1
• Gene: trk-1 / 183575
• WormBaseID: WBGene00017039
• Length: 842
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 150/600 - (25%)
• Similarity: 231/600 - (38%)
• Gaps: 163/600 - (27%)

  Fly   324 PGGIPTPGTPNSKAKDN-----------------SHFVKLVVALYPFKAIEGGDLSLEKNAEYEV 371
            ||.:..||...||..||                 ..:.....:.:|.|..|   :..||.|:..:
 Worm   159 PGKMMFPGVIYSKNGDNVTVHVGFDDQVLNRTIDKPYFDWAFSKHPHKHEE---IIAEKGADLMI 220

  Fly   372 IDDSQEHW-------WKVKDALGNVGYIP--SNYVKPKALLG---------------LERYEWYV 412
            .:..:|..       |...|.|  ||.|.  :||....|.:.               ::.....:
 Worm   221 TNLKREDMGVIGVKCWHCLDFL--VGKIELRANYPVKVAFVDKTRLDTDFLVVTGYPIDNISMAI 283

  Fly   413 GDMSRQRAESLLKQGDKEGCF----VVRKSSTKGLY--TLSLHTK--VPQSHVK---HYHIKQNA 466
            ..|....:|:.....:|:..|    |||.......|  |..:.||  ....|:.   .:.:..|.
 Worm   284 TKMQSNYSETNFVGREKDAIFFSSLVVRMEKRPLFYQKTYRVFTKDAAEGDHLSGDLRFEVCTNG 348

  Fly   467 RCEYYLSEKHCCE------TIPDLI-----------------------------NYHR------- 489
            .|:  ..|||...      ||.|.|                             .|||
 Worm   349 SCD--AIEKHVSHLGLINGTIDDFIIVEYPYKQEIQIVVFLIVICLLIVVSALAFYHRLKLQSFL 411

  Fly   490 -------HNSGGLACRLKSSPCDRPVPPT-------AGLSHD------------KWEIHPMELML 528
                   .....||..|::....:....|       :.|:.|            ..|||.|
 Worm   412 REKILSFRKRISLAQELQTRRASQETEETLLRLEERSSLASDYTNMTLPFIDMGNIEIHEM---- 472

  Fly   529 MEELGSGQFGVVRRGKW--RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
               ||.|.||.|....|  .|....|||.::...|:.:   :||:|:..|:|||:|:|||:...:
 Worm   473 ---LGKGHFGEVYLASWDYTGPRSVAVKSIRRVDMATE---KEARVLQDLEHPNIVKLYGMTRNN 531

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKT----LIGNMGLLLD----MCIQVSKGMTYLERHNYIHRDL 648
            ..:.:|.|:|.||.|..||.:....    |.....|::|    :..:::.|:.||...:.:||||
 Worm   532 FNLLLVFEHMNHGDLKTYLEQRAPVKSVYLQYPPPLVIDELKWIIKEITTGLVYLVEQSIVHRDL 596

  Fly   649 AARNCLVGSEN-------------VVKVADFGLARYVLD--DQYTSSGGTKFPIKWAPPEVLNYT 698
            |||||||..::             .||::|||::|.:.|  :.||.......|::|.|||.:...
 Worm   597 AARNCLVAGDSDLKATSHFERPPIRVKISDFGMSRRLYDHSEYYTMDHRGALPVRWLPPEAVQSH 661

  Fly   699 RFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHG 763
            :|:..||:|:.||.|||..:.|:.|:..|.|.||......|:...||:.|.:::||:|..||...
 Worm   662 KFTYNSDIWSLGVTMWECMSYGRQPFDGLSNLEVSSFTLAGMRPLKPERCPQDMYDLMVKCWHME 726

  Fly   764 PEER-PAFRVLMDQL 777
            |.:| .|.::|.|:|
 Worm   727 PVKRITAKQILEDEL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	15/61 (25%)
		SH2_Tec_family	403..505	CDD:198188	27/176 (15%)
		PTKc_Tec_like	521..778	CDD:173637	94/282 (33%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	90/276 (33%)