Protein Alignment Btk and C25A8.5

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_501081.1
• Gene: C25A8.5 / 182879
• WormBaseID: WBGene00016085
• Length: 416
• Species: Caenorhabditis elegans
• Alignment Length: 402
• Identity: 128/402 - (31%)
• Similarity: 204/402 - (50%)
• Gaps: 64/402 - (15%)

  Fly   410 WYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKG----LYTLSL--HTKVPQSHVKHYHIKQNARC 468
            ||.|.:.|:..:::|:   |.|.|:||.:..|.    .|.||.  ..::..:.||||.::.|...
 Worm    11 WYHGLLPREDIKAMLR---KNGDFLVRSTEPKAGEPRQYVLSAMQSEELEDAGVKHYVMRLNPSN 72

  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELG 533
            :.:|..|. .|||..|:||:.::         ..|..:.......:....|||...::.|.::||
 Worm    73 QIFLEAKG-FETIASLVNYYMNS---------KEPIKKMTVLKTPILKQPWEIEHSQVELTKKLG 127

  Fly   534 SGQFGVVRRGKW---RGSIDT-AVKMMKEGTMSED---DFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            .|.||.|.:||.   .|:::. |:|..|..:::::   :.:.||::|..|.|||:|:.|||.:..
 Worm   128 EGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQ 192

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            .|:|::.|....|:|.:||:::...|.|..   ::|..|.:.|:.|:.....:|||:||||||.|
 Worm   193 EPLYVIMELADCGALDSYLQKNPNLLPGKK---MEMIYQAACGIAYMHEKKLLHRDIAARNCLYG 254

  Fly   657 SENVVKVADFGLAR----YVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF 717
             |..||:|||||:|    ||:|  .|.    |.||:|..||.|....:|.||||:|:|::.|||.
 Worm   255 -EGQVKIADFGLSREGNSYVMD--LTK----KVPIRWLAPETLKAGIYSPKSDVFAFGIMAWEIT 312

  Fly   718 TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYD-----------VMKLCWSHGPEERPAFR 771
            ..||.||..::.:|||..|:.|..:.         :|           |.|.||:..|::    |
 Worm   313 ENGKEPYPDMRVSEVVGYVRSGHRMR---------FDPVFVDFRFGEYVTKHCWAENPDD----R 364

  Fly   772 VLMDQLALVAQT 783
            |.|..:....||
 Worm   365 VNMSDVLRYLQT 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	28/100 (28%)
		PTKc_Tec_like	521..778	CDD:173637	96/278 (35%)
C25A8.5	NP_501081.1	SH2_Fps_family	4..98	CDD:198224	27/99 (27%)
		PTKc	124..375	CDD:270623	94/273 (34%)