Protein Alignment Btk and abl-1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_509778.2
• Gene: abl-1 / 181261
• WormBaseID: WBGene00000018
• Length: 1224
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 189/513 - (36%)
• Similarity: 287/513 - (55%)
• Gaps: 47/513 - (9%)

  Fly   292 TPTSLQ-----------PQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVK 345
            ||.|:|           |.|..:||:.|    .....|:..:....:......|:.:..:|....
 Worm    58 TPDSVQMFRPTFDTFRPPNSDSSTFRGS----QSREDLVACSSMNSVNNVHDMNTVSSSSSSSAP 118

  Fly   346 LVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW--------KVKDA-----LGNVGYIPSNYV 397
            |.||||.|..:....|||.|..:..::..::.:.|        :..||     ||.:|::|||::
 Worm   119 LFVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFI 183

  Fly   398 KPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTK-GLYTLSLHTKVPQSHVKHYH 461
            .|  ...|::|.||.|.:||..:|::|..| ..|.|:||:|.|. |.||:|:.   ....|.||.
 Worm   184 AP--YNSLDKYTWYHGKISRSDSEAILGSG-ITGSFLVRESETSIGQYTISVR---HDGRVFHYR 242

  Fly   462 IKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRL--KSSPCDR-----PVPPTAGLSHDKW 519
            |..:...:.:::::....|:.:|:::|..::.||.|.|  .:|..|:     .:.|.|   .|:|
 Worm   243 INVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNA---PDEW 304

  Fly   520 EIHPMELMLMEELGSGQFGVVRRGKW-RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQ 583
            |:...|:::..:||.||:|.|..|.| |.....|||.:||..|...:|:.||.:|..|.|.|||:
 Worm   305 ELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVR 369

  Fly   584 LYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDL 648
            |.|||:...|.||:||:|.:|:||.||||.:|:|:..: :|:.|..|::.||:|||..::|||||
 Worm   370 LLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPI-ILVQMASQIASGMSYLEARHFIHRDL 433

  Fly   649 AARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLM 713
            |||||||...|:||:|||||||::.:|.||:..|.||||||..||.|.:..|||||||||:|||:
 Worm   434 AARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLL 498

  Fly   714 WEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFR 771
            |||.|.|..||..::.:.|...::.|..::.|:.|...:|.:|..||:..|.:||.||
 Worm   499 WEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFR 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/65 (29%)
		SH2_Tec_family	403..505	CDD:198188	32/104 (31%)
		PTKc_Tec_like	521..778	CDD:173637	119/252 (47%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	19/65 (29%)
		SH2_ABL	190..283	CDD:198189	30/96 (31%)
		PTKc_Abl	304..566	CDD:270645	121/254 (48%)
		FABD	1091..1224	CDD:197885