DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and nck-1

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001361996.1 Gene:nck-1 / 180690 WormBaseID:WBGene00006410 Length:397 Species:Caenorhabditis elegans


Alignment Length:372 Identity:91/372 - (24%)
Similarity:145/372 - (38%) Gaps:111/372 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 IANSEKE----RSEWIRAIR------QVCEDSNT----PKSYRYH-----------PGLWSGKKW 204
            :|..|:|    ::|.::.:.      :|..|||:    |.:|...           .||..|:..
 Worm    13 LAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSVGFVPSNYVRKESIVDKAKGTIKGLARGRNR 77

  Fly   205 SC-------CKGLSRTTFGCRAAAHWREANNN----PSNGSSPAQNS-TRSISPNSSTTNSQFSL 257
            |.       ..|::|..|         ..|||    ||:...|..:| |:::        .:|:.
 Worm    78 SSDPEPEERLNGIARLAF---------SLNNNCAVTPSSNKIPMMSSKTKAV--------VKFTY 125

  Fly   258 QHNSSGSLGGGVGGGLGGGGSLGL----------GGGGGGGGSCTPTSLQPQSSLTTFKQSPTLL 312
            :......|      ||..|..:.:          |....||....|::...:...:|        
 Worm   126 EPRLEDEL------GLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEAST-------- 176

  Fly   313 NGNGTLLDANMP--GGIPTP-----GTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYE 370
            |||...::...|  ..:|.|     ..|..:|..:|..:::|||||.|.|....:||.:|....|
 Worm   177 NGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDASSSEELSFKKGERLE 241

  Fly   371 VIDDSQEH---WWKVKDALGNVGYIPSNYVK-------PKAL-------------LGLERYEWYV 412
            :: |..||   ||..::|.|..|.:|.||::       .||.             :.:|:..||.
 Worm   242 IV-DHPEHDPDWWMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYF 305

  Fly   413 GDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVK 458
            |.:||:|||.||..| :||.|:||.| |..|..::|:.......|.|
 Worm   306 GRISRERAEDLLLHG-REGEFLVRDSESNPGDLSISMRGIERNKHFK 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944 17/88 (19%)
SH3_Tec_like 346..399 CDD:212702 22/62 (35%)
SH2_Tec_family 403..505 CDD:198188 23/57 (40%)
PTKc_Tec_like 521..778 CDD:173637
nck-1NP_001361996.1 SH3_Nck_1 5..55 CDD:212699 9/41 (22%)
SH3_Nck_2 118..171 CDD:212700 9/66 (14%)
SH3_Nck_3 217..272 CDD:212701 22/55 (40%)
SH2_Nck_family 301..392 CDD:198196 22/52 (42%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.