Protein Alignment Btk and rol-3

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001256097.1
• Gene: rol-3 / 179204
• WormBaseID: WBGene00004395
• Length: 2481
• Species: Caenorhabditis elegans
• Alignment Length: 913
• Identity: 196/913 - (21%)
• Similarity: 348/913 - (38%)
• Gaps: 226/913 - (24%)

  Fly    12 NGSIKSSSSLRSSSKSFQAK--MDLMSER--LYDVV---KSGSM--VKRAQNKKRFTPVNYKHRW 67
            |..:|...::..||:.:..:  .:|.|.:  ::.:|   |:||.  |.::.:......|:.....
 Worm  1413 NPPLKQILAVSQSSQPYPERSCFELPSSKGIVFSIVNEGKTGSFLEVTKSSSSSSCQEVSMPQTQ 1477

  Fly    68 FELTKRTFSYFDVENVER----RRERGRIHLKGVRLVEE-------------ATVSGEGGDPFAP 115
            :|:      ||..:|.::    |....|||::...|.:|             :..||.....
 Worm  1478 YEI------YFTRKNTDKVKHVRSFSDRIHVENGILDKETDYDVTVTWLNRYSPASGVSASK--- 1533

  Fly   116 DGYPFQVGYCEISASANSHQL--------------ENGNGGGSGV--GIEGQQSGRAVPQYTLYV 164
               .|:.|:...||..:.|.:              |..|...|.:  .|..|.:|.:||. ::.|
 Worm  1534 ---SFRTGFGYPSAPRDPHAIPVTPDTVYLYWNLPETLNAPISEIKYKISQQAAGISVPT-SIAV 1594

  Fly   165 IANSEKERSEWIRAIRQVC-------EDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAH 222
            ||.||...|. |.:....|       :.:|...|..|       |.|.....:|...    ||..
 Worm  1595 IALSETVSSN-ISSDTTSCLINPCRVKIANLRPSNEY-------KFWVTATHISHLD----AATI 1647

  Fly   223 WREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHN--------SSGSLGGGVGGGLGGGGSL 279
            .::.:...|...:...:...::.|: :.|.|...|:.|        ||.::.....||.......
 Worm  1648 LKDDDAVSSEAVARTLDVPGTLRPD-NVTGSSLLLRWNGLEPEHRPSSIAVQYRESGGANNEWQF 1711

  Fly   280 GLGGGGGGGGSCTP---TSLQPQSSL-----------TTFKQSPTLLNGNGTLL----------- 319
            .:      ..|..|   |.|.|.::|           .|:..:.|:   :|.:|
 Worm  1712 PM------NVSFEPDVTTELVPITNLLSATSYDYRFVATYTGTYTI---DGKVLAFKEDYLQLPQ 1767

  Fly   320 DANMPGGIPT-PGTPNSKAKDNSHFVKLVVALYPFKAIEGG--------DLSLEKNAEYEVID-- 373
            .|....|:|| |....:|..:....|     .:.....:||        :..:.|.||:|:.:
 Worm  1768 QARTKAGVPTAPQFVEAKQDEEGWIV-----TWKEPMSDGGSPITSYAVETRINKTAEWEIAERG 1827

  Fly   374 -DSQEHWWK--VKDALGNVG----YIPSNYVKPKALLGLERYEWYVGDMSRQRAES--------- 422
             |..:.||:  ..|...:..    .:....::...:.|...|. |..|...::.|.
 Worm  1828 LDGWKTWWRPGKSDTTSSTSTSSTEVSEFRIRAANIEGFGAYA-YTEDKKEEKEEEPSSVLPYLL 1891

  Fly   423 ------LLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI 481
                  ||.......||.::                  |..:....|:.|.     .|::|...
 Worm  1892 LLSIIFLLAAMILVACFWLK------------------SRRRQQQKKREAE-----DERNCIRL- 1932

  Fly   482 PDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLM--------EELGSGQFG 538
             |::           ..:..|...:.:||       ::|.....|.::        :.:.:..:|
 Worm  1933 -DVV-----------ANMNFSSSHQSLPP-------EYESEMRNLPVVNYSTVTFNDYIDTCAYG 1978

  Fly   539 VVRRG-------KWRGSIDTAVKMMKEGTMSEDD--FIEEAKVMTKLQHPNLVQLYGVCSKHRPI 594
            :|..|       .|...:..|:|.:|.....::.  |::||.::..|.|||:|:..|||......
 Worm  1979 IVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQE 2043

  Fly   595 YIVTEYMKHGSLLNYLRRHEKTLIGNMGL----LLDMCIQVSKGMTYLERHNYIHRDLAARNCLV 655
            .|:.|||:.|:||.:|::.......:..|    ||.:.:.:::||.||||..::|::|:||.||:
 Worm  2044 LILLEYMEGGNLLKFLQKSTPNEYQSSELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLL 2108

  Fly   656 GSENVVKVADFGLARYVLDDQYTSSGGTKFPI-KWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC 719
            .....|...:.|:::.:.:.|...|......| :|..||||...:|||||||||||||::|:|:.
 Worm  2109 AGRPGVTKLEMGMSKELSNGQVNRSDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSF 2173

  Fly   720 GKMPYGRLKNTEVVERVQRGIILEKPKSC-AKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
            |::|||...|..::..|:.|.:|..|..| :|.||.|:|.|.:....:|..|..::.    :.:|
 Worm  2174 GEVPYGDKDNRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILK----IFET 2234

  Fly   784 LTD 786
            ..|
 Worm  2235 FRD 2237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	46/219 (21%)
		SH3_Tec_like	346..399	CDD:212702	10/69 (14%)
		SH2_Tec_family	403..505	CDD:198188	16/116 (14%)
		PTKc_Tec_like	521..778	CDD:173637	85/279 (30%)
rol-3	NP_001256097.1	FN3	<1476..1834	CDD:442628	75/397 (19%)
		fn3	1543..1636	CDD:394996	24/101 (24%)
		STYKc	1966..2232	CDD:214568	84/269 (31%)